--- title: Do plant compounds help irregular periods and PMS? | Niyora description: Yes. All 15 women developed more regular cycles averaging 27.1 ± 3.2 days with reduced menstrual pain and flow. In the 7 women with PMS, depression, headache, url: https://niyora.com/research/papers/phyto-progestins-for-the-treatment-of-abnormal-uterine-bleeding-without-organic-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do plant compounds help irregular periods and PMS? Cohort study, 2023 # Do plant compounds help irregular periods and PMS? Yes. All 15 women developed more regular cycles averaging 27.1 ± 3.2 days with reduced menstrual pain and flow. In the 7 women with PMS, depression, headache, and abdominal pain improved. The study was very small without a control group. Early or limited evidence 15 women at genetic risk for or with breast cancer history with irregular periods ## What they did 15 women at genetic risk for breast cancer or with breast cancer history who had irregular periods (cycles of 24 days or fewer, or 38 days or more) received a daily combination of three plants: Dioscorea villosa, Vitex agnus castus, and Turnera diffusa. They tracked bleeding daily and completed quality-of-life questionnaires for 3 months. ## What they found All 15 women developed regular cycles with mean length 27.1 ± 3.2 days. Menstrual pain and flow intensity significantly decreased (p=0.02). Among 7 women with PMS, depression, headache, and abdominal pain scores improved significantly (p<0.05). Overall satisfaction was 6.8 out of 10. ## What it means for you A combination of three plants may help regulate periods and reduce menstrual pain, with possible PMS benefits in breast cancer survivors. Very limited by small sample size (15 women), no control group, and only 3 months of follow-up. 15 women in study 27.1±3.2 days mean cycle length after treatment 7 women with PMS symptom improvement ## About the study Original title Phyto-progestins for the treatment of abnormal uterine bleeding without organic cause in women at high risk for breast cancer and breast cancer survivors: a prospective, pilot study Authors Grandi G, Facchinetti F, Melotti C et al. Journal Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Year 2023 Study design Cohort study Participants 15 What was tested Daily combination of Dioscorea villosa, Vitex agnus castus, Turnera diffusa for 3 months Open access Yes Read the paper [doi.org/10.1080/09513590.2023.2239936](https://doi.org/10.1080/09513590.2023.2239936) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Quality of life and daily functioning](https://niyora.com/research/topics/life-area-quality-of-life/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Cohort study, 2024 Does Vitex supplement improve menstrual cycle problems and quality of life? Randomised trial, 2026 Do seed cycling capsules with chasteberry reduce PMS symptoms over two months? Review, 2025 Do herbal remedies help with menstrual and menopausal symptoms? Non-randomised trial, 2023 Does a supplement with Vitex, vitamin B6, and magnesium reduce PMS symptoms? Systematic review, 2025 Does digital healthcare help manage period pain and PMS? Systematic review, 2025 Does teaching adolescent girls about their menstrual cycle and health help reduce period pain and PMS? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗