--- title: Does magnesium supplementation reduce PMS symptoms? | Niyora description: Yes, magnesium supplementation significantly reduced PMS symptoms after 3 months, with symptom scores decreasing by about 35 percent. However, this study had url: https://niyora.com/research/papers/pilot-study-of-the-efficacy-and-safety-of-a-modified-release-magnesium-250-mg-2007/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does magnesium supplementation reduce PMS symptoms? Non-randomised trial, 2007 # Does magnesium supplementation reduce PMS symptoms? Yes, magnesium supplementation significantly reduced PMS symptoms after 3 months, with symptom scores decreasing by about 35 percent. However, this study had no placebo control, so some improvement could be due to placebo effect. Early or limited evidence 41 women aged 18 to 45 with regular menstrual cycles (25 to 35 days) and PMS ## What they did 41 women aged 18 to 45 with PMS took a modified-release magnesium tablet containing 250 mg for 3 menstrual cycles. Treatment started 20 days after the beginning of their menstrual period and continued until the next period began. They had a 3-month observation period before starting treatment. ## What they found After 3 months, the mean total PMS score was significantly lower than before treatment (p less than 0.0001). Patient diary scores also showed significant improvements (p less than 0.0001 for all subscales). The relative decrease in total PMS scores was 35.1 percent as assessed by the investigator and 33.5 percent as recorded by patients in their diaries. The magnesium was well tolerated. Only one patient reported a treatment-related adverse event, which was vertigo. ## What it means for you Magnesium supplementation appears to reduce PMS symptoms substantially and was well tolerated. However, this was an open-label study where women knew they were receiving magnesium, without a placebo control group. Therefore, some improvement could be due to placebo effect. The results are preliminary and need confirmation in a larger controlled study. 41 women 250 mg dose of magnesium 35.1% decrease in PMS scores ## About the study Original title Pilot study of the efficacy and safety of a modified-release magnesium 250 mg tablet (Sincromag) for the treatment of premenstrual syndrome Authors Quaranta S, Buscaglia MA, Meroni MG et al. Journal Clinical drug investigation Year 2007 Study design Non-randomised trial Participants 41 What was tested Modified-release magnesium tablet 250 mg for 3 menstrual cycles Read the paper [doi.org/10.2165/00044011-200727010-00004](https://doi.org/10.2165/00044011-200727010-00004) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2026 Can diet and nutrition help reduce PMS symptoms? Review, 2025 Do yoga and dietary changes help with PMS symptoms? Survey study, 2025 Do certain nutrients and body weight affect PMS? Review, 2023 Can herbs and supplements help with PMS symptoms? Cohort study, 2020 Are calcium and magnesium levels lower in women with PMS? Survey study, 2019 Do women with PMS have different nutrient levels than healthy women? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗