---
title: Is monoamine oxidase B activity different in women with PMS? | Niyora
description: No, there were no significant differences between women with PMS and controls in monoamine oxidase B activity. This suggests this enzyme is not involved in PM
url: https://niyora.com/research/papers/platelet-monoamine-oxidase-b-activity-in-women-with-premenstrual-syndrome-1988/
---

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- Is monoamine oxidase B activity different in women with PMS?

Case-control study, 1988

# Is monoamine oxidase B activity different in women with PMS?

No, there were no significant differences between women with PMS and controls in monoamine oxidase B activity. This suggests this enzyme is not involved in PMS, though the study was small.

 Early or limited evidence

13 women with premenstrual syndrome and 19 control subjects

## What they did

Case-control study measuring platelet monoamine oxidase B activity, estradiol, and progesterone throughout one menstrual cycle in women with PMS and control subjects.

## What they found

No significant differences were noted between women with PMS and control subjects in monoamine oxidase B activity, estradiol, or progesterone levels. The study indicates that well-screened women with PMS are biochemically similar to normal controls on these measures.

## What it means for you

This enzyme does not appear to be involved in PMS. The main limitations are the small sample size and that this is just one enzyme among many that affect mood and brain function.

13

Women with premenstrual syndrome

19

Control women

1

Menstrual cycles tracked per woman

## About the study

Original title Platelet monoamine oxidase B activity in women with premenstrual syndrome Authors Rapkin AJ, Buckman TD, Sutphin MS et al. Journal American journal of obstetrics and gynecology Year 1988 Study design Case-control study Participants 19 What was tested None Read the paper [doi.org/10.1016/0002-9378(88)90590-x](https://doi.org/10.1016/0002-9378(88)90590-x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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