---
title: What treatments work best for PMDD? | Niyora
description: Exercise, diet changes, minerals, and medicines that stop ovulation all help, with SSRIs appearing most effective. Start with non-medication approaches first.
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-current-status-of-treatment-2002/
---

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- What treatments work best for PMDD?

Review, 2002

# What treatments work best for PMDD?

Exercise, diet changes, minerals, and medicines that stop ovulation all help, with SSRIs appearing most effective. Start with non-medication approaches first.

 Strong study design

Systematic review of randomized trials for PMDD treatment

## What they did

This systematic review searched medical databases for all randomized trials testing PMDD treatments published between 1983 and 2001.

## What they found

Physical activity, dietary change, mineral salt supplementation, and ovulation inhibitors all appear effective. SSRIs are the most effective treatment overall.

## What it means for you

Multiple treatments work for PMDD, so women should try non-medication approaches first and then consider medications if those do not help. This analysis is limited to randomized trials published before 2002.

## About the study

Original title Premenstrual dysphoric disorder: current status of treatment Authors Bianchi-Demicheli F, Lüdicke F, Lucas H et al. Journal Swiss medical weekly Year 2002 Study design Review What was tested None (systematic review of trials) Open access Yes Read the paper [doi.org/10.4414/smw.2002.10055](https://doi.org/10.4414/smw.2002.10055)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Does taking sertraline when PMDD symptoms start improve how well women function?

Guideline, 2006

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Case report, 2024

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Study, 2008

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Study, 2008

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