---
title: How does sertraline affect thinking in women with PMDD? | Niyora
description: One female aviator with PMDD received sertraline 25 mg daily for 5-7 days per month and had her thinking and attention assessed while on and off the medicatio
url: https://niyora.com/research/papers/premenstrual-dysphoric-disorder-treatment-with-sertraline-neuropsychological-2007/
---

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- How does sertraline affect thinking in women with PMDD?

Case report, 2007

# How does sertraline affect thinking in women with PMDD?

One female aviator with PMDD received sertraline 25 mg daily for 5-7 days per month and had her thinking and attention assessed while on and off the medication. The report interprets her neuropsychological performance and discusses potential cognitive effects.

 Early or limited evidence

One female aviator with PMDD

## What they did

Tested one female aviator with PMDD on two occasions: once while taking sertraline 25 mg daily for 5-7 days per month, and once while not taking it. Both tests were on day 6 of her menstrual cycle. She also had a blinded flight evaluation by a pilot both times.

## What they found

The report interprets her thinking and attention while on and off sertraline and discusses how this relates to her ability to fly safely.

## What it means for you

This case examined a female pilot's thinking and flight safety while on and off sertraline for PMDD. As a single case, it can only describe one person's experience, not what would happen for others.

25 mg

daily sertraline dose

5-7

days per month of medication

## About the study

Original title Premenstrual dysphoric disorder: treatment with sertraline, neuropsychological effects, and flight status Authors Kratz K, Anderson S, Poppen B Journal Aviation, space, and environmental medicine Year 2007 Study design Case report What was tested Sertraline 25 mg daily for 5-7 days per month Read the paper [https://pubmed.ncbi.nlm.nih.gov/17547314/](https://pubmed.ncbi.nlm.nih.gov/17547314/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Systematic review, 2024

Do SSRI antidepressants help treat PMS and PMDD?

Review, 2017

What causes PMDD and what are the best treatments?

Review, 2015

What do we know about PMS and PMDD and how are they treated?

Systematic review, 2012

How effective are cognitive-behavioral therapy and antidepressants for PMS and PMDD?

Review, 2011

What are PMS and PMDD, and how common are they?

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