---
title: Can mood disorders get worse before your period? | Niyora
description: Yes. Mood disorders can worsen before the period. This is different from PMDD and PMS but it is not well understood.
url: https://niyora.com/research/papers/premenstrual-exacerbations-of-mood-disorders-2001/
---

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- Can mood disorders get worse before your period?

Review, 2001

# Can mood disorders get worse before your period?

Yes. Mood disorders can worsen before the period. This is different from PMDD and PMS but it is not well understood.

 Early or limited evidence

Review of research on mood disorder exacerbations

## What they did

Reviewed research on how mood disorders worsen premenstrually.

## What they found

Mood disorders can worsen before the period (premenstrual magnification). This is different from PMDD and PMS. It is unclear whether women can have both a mood disorder and PMDD at the same time.

## What it means for you

If you have both a mood disorder and premenstrual worsening, it is important to get the right diagnosis because they may need different treatments. More research is needed to understand how these are related.

## About the study

Original title Premenstrual exacerbations of mood disorders Authors Miller MN, Miller BE Journal Psychopharmacology bulletin Year 2001 Study design Review What was tested Not applicable - literature review Read the paper [doi.org/10.64719/pb.4258](https://doi.org/10.64719/pb.4258)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Survey study, 2006

Does the menstrual cycle affect mood disorders?

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Randomised trial, 2000

How should PMDD be diagnosed and treated?

Survey study, 2026

What is the true rate of PMDD, and does it worsen mental health conditions?

Survey study, 2011

How common is PMDD in women with depression compared to healthy women?

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