---
title: Can women with premenstrual mood changes develop serious mood disorders?
description: In some women with premenstrual mood changes, a serious mood disorder called manic-depressive illness may develop, but mainly in those with genetic predisposi
url: https://niyora.com/research/papers/premenstrual-mood-changes-in-affective-disorders-1987/
---

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- Can women with premenstrual mood changes develop serious mood disorders?

Case report, 1987

# Can women with premenstrual mood changes develop serious mood disorders?

In some women with premenstrual mood changes, a serious mood disorder called manic-depressive illness may develop, but mainly in those with genetic predisposition. Doctors should watch for severe mood problems after pregnancy in women with this pattern.

 Early or limited evidence

3 women with premenstrual mood changes who developed manic-depressive illness

## What they did

Described 3 women who had mood swings tied to their menstrual cycle and then developed manic-depressive illness that required intensive psychiatric treatment or hospital admission.

## What they found

All 3 women had a pattern of mood changes during their menstrual cycle, followed by development of manic-depressive illness.

## What it means for you

Women with premenstrual mood swings might be at risk of developing manic-depressive illness if they have the genetic background for it. The main limitation is that this comes from just 3 cases, so we don't know how common this pattern is.

## About the study

Original title Premenstrual mood changes in affective disorders Authors Ghadirian AM, Kamaraju LS Journal CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne Year 1987 Study design Case report What was tested None Open access Yes Read the paper [doi.org/10.17615/7g4c-3b34](https://doi.org/10.17615/7g4c-3b34)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Bipolar disorder](https://niyora.com/research/topics/comorbidity-bipolar/)

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## Related studies

Cohort study, 2023

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Do anxiety and depression get worse before your period if you already have a mental health condition?

Survey study, 2026

What is the true rate of PMDD, and does it worsen mental health conditions?

Survey study, 2025

Do women with bipolar disorder who had PMS or postpartum depression have worse mood problems during menopause?

Cohort study, 2022

Do women with both bipolar disorder and PMDD have worse biological rhythm disruptions?

Review, 2014

Does the menstrual cycle affect mood episodes in women with bipolar disorder?

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