---
title: Do skin diseases in women with PMS relate to allergic reactions to female sex hormones?
description: Women with PMS showed allergic reactions to female sex hormones whether or not they had skin problems. Desensitization treatment improved both PMS symptoms an
url: https://niyora.com/research/papers/premenstrual-syndrome-and-associated-skin-diseases-related-to-hypersensitivity-2004/
---

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- Do skin diseases in women with PMS relate to allergic reactions to female sex hormones?

Case-control study, 2004

# Do skin diseases in women with PMS relate to allergic reactions to female sex hormones?

Women with PMS showed allergic reactions to female sex hormones whether or not they had skin problems. Desensitization treatment improved both PMS symptoms and skin disease.

 Early or limited evidence

30 women: 10 with PMS and skin disease, 10 with PMS without skin disease, 10 healthy women

## What they did

This case-control study examined 30 women: 10 with PMS and skin disease, 10 with PMS but no skin disease, and 10 healthy women. Researchers tested their skin with female sex hormones to look for allergic reactions and gave desensitization treatment to 15 of the women with PMS.

## What they found

All 20 women with PMS showed allergic reactions to the sex hormones tested, but none of the 10 healthy women did. Women who received desensitization treatment had improvements in both their PMS symptoms and skin disease.

## What it means for you

This very small study suggests some PMS-related skin problems might be due to allergic reactions to hormones. The findings need testing in larger groups of women before doctors could rely on them.

30

Total women studied

20

Women with PMS who showed allergic reactions

15

Women who received desensitization treatment

## About the study

Original title Premenstrual syndrome and associated skin diseases related to hypersensitivity to female sex hormones Authors Itsekson A, Lazarov A, Cordoba M et al. Journal The Journal of reproductive medicine Year 2004 Study design Case-control study Participants 15 What was tested Desensitization treatment Read the paper [https://pubmed.ncbi.nlm.nih.gov/15098889/](https://pubmed.ncbi.nlm.nih.gov/15098889/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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