---
title: How should PMS and PMDD be managed? | Niyora
description: SSRIs are the most effective treatment for PMDD and can be taken daily or just during the premenstrual week, with excellent results and minimal side effects.
url: https://niyora.com/research/papers/premenstrual-syndrome-and-premenstrual-dysphoric-disorder-guidelines-for-2000/
---

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- How should PMS and PMDD be managed?

Randomised trial, 2000

# How should PMS and PMDD be managed?

SSRIs are the most effective treatment for PMDD and can be taken daily or just during the premenstrual week, with excellent results and minimal side effects.

 Strong study design

Women with PMS and PMDD (guideline update)

## What they did

Clinical guidelines and expert update on managing PMS and PMDD based on research evidence.

## What they found

PMDD affects 3 to 8% of women, compared to 75% with some PMS symptoms. SSRIs have excellent efficacy and minimal side effects in randomized trials. Intermittent SSRIs (taken only premenstrually) are equally effective as daily dosing.

## What it means for you

SSRIs are the best current treatment for PMDD and can be used flexibly. Women can work with their doctor to find what works best. Guidelines can become outdated as new research emerges.

3% to 8%

Women with PMDD

75%

Women with some PMS symptoms

## About the study

Original title Premenstrual syndrome and premenstrual dysphoric disorder: guidelines for management Authors Steiner M Journal Journal of psychiatry & neuroscience : JPN Year 2000 Study design Randomised trial What was tested SSRIs (daily or intermittent), lifestyle and stress management Open access Yes Read the paper [https://pubmed.ncbi.nlm.nih.gov/11109297/](https://pubmed.ncbi.nlm.nih.gov/11109297/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Review, 2018

What are the most effective treatments for premenstrual syndrome and PMDD?

Randomised trial, 2000

How should PMDD be diagnosed and treated?

Randomised trial, 2000

How effective are antidepressants for treating PMDD?

Study, 2026

Do anxiety and depression get worse before your period if you already have a mental health condition?

Survey study, 2026

What is the true rate of PMDD, and does it worsen mental health conditions?

Guideline, 2006

What is the best treatment for PMDD and severe PMS?

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