---
title: Does higher progesterone dose work better for PMS? | Niyora
description: No. The researchers found that symptoms improved in both the progesterone group and placebo group when more suppositories were given, suggesting higher doses
url: https://niyora.com/research/papers/premenstrual-syndrome-and-progesterone-suppositories-reply-1991/
---

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- Does higher progesterone dose work better for PMS?

Randomised trial, 1991

# Does higher progesterone dose work better for PMS?

No. The researchers found that symptoms improved in both the progesterone group and placebo group when more suppositories were given, suggesting higher doses do not add extra benefit.

 Early or limited evidence

Women with PMS (specific numbers unclear from this reply letter)

## What they did

This is a response to criticism of the authors' earlier progesterone study. They reviewed findings from a placebo-controlled trial using 400-mg progesterone suppositories and measured blood progesterone levels.

## What they found

Symptoms decreased for both the progesterone group and placebo group when the number of suppositories was increased.

## What it means for you

Since both groups improved together with more treatment, this suggests improvement may not be due to progesterone itself. Higher doses may not be more effective than lower doses. Main limits: reply letter with incomplete information.

400 mg

dose of suppositories

## About the study

Original title Premenstrual Syndrome and Progesterone Suppositories-Reply Authors Ellen W. Freeman Journal JAMA Year 1991 Study design Randomised trial What was tested Progesterone suppositories 400-mg Read the paper [doi.org/10.1001/jama.1991.03460010026012](https://doi.org/10.1001/jama.1991.03460010026012)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

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