---
title: Do women with PMS have worse menopausal symptoms? | Niyora
description: Yes, women with PMS are significantly more likely to experience hot flushes, depression, poor sleep, and low libido during menopause. This large five-year stu
url: https://niyora.com/research/papers/premenstrual-syndrome-as-a-predictor-of-menopausal-symptoms-2004/
---

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- Do women with PMS have worse menopausal symptoms?

Cohort study, 2004

# Do women with PMS have worse menopausal symptoms?

Yes, women with PMS are significantly more likely to experience hot flushes, depression, poor sleep, and low libido during menopause. This large five-year study provides strong evidence for this connection.

 Strong study design

436 women in the transition to menopause, followed for 5 years.

## What they did

A five-year follow-up study of 436 women transitioning to menopause. Researchers collected structured interviews, daily symptom ratings, depression and sleep measures at seven timepoints, and hormone measurements across the menstrual cycle.

## What they found

Women who reported PMS at the start were more likely over the five years to experience hot flushes (odds ratio 2.09), depression (OR 2.34), poor sleep (OR 1.72), and decreased libido (OR 1.54) after adjusting for age, race, depression history, and estradiol levels.

## What it means for you

Women who experience PMS appear to be at higher risk for certain menopausal symptoms like hot flushes and depression. This study's large sample size and five-year follow-up provide strong evidence, though biological mechanisms remain unclear.

436

Women followed

5 years

Study duration

2.09

Increased risk of hot flushes with PMS

## About the study

Original title Premenstrual syndrome as a predictor of menopausal symptoms Authors Freeman EW, Sammel MD, Rinaudo PJ et al. Journal Obstetrics and gynecology Year 2004 Study design Cohort study Participants 436 What was tested None; observational study. Read the paper [doi.org/10.1097/01.aog.0000124804.81095.7f](https://doi.org/10.1097/01.aog.0000124804.81095.7f)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Sleep and insomnia](https://niyora.com/research/topics/symptom-sleep/)[Libido and sexual function](https://niyora.com/research/topics/symptom-sexual-function/)[Major depressive disorder](https://niyora.com/research/topics/comorbidity-major-depression/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

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Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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