---
title: Does the flavonoid supplement Daflon 500 mg reduce PMS symptoms?
description: Yes, though results need confirmation. PMS disappeared completely in 37.4 percent. Duration dropped 2.6 days. Bloating decreased 60 percent. But there was no
url: https://niyora.com/research/papers/premenstrual-syndrome-in-france-epidemiology-and-therapeutic-effectiveness-of-1997/
---

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- Does the flavonoid supplement Daflon 500 mg reduce PMS symptoms?

Non-randomised trial, 1997

# Does the flavonoid supplement Daflon 500 mg reduce PMS symptoms?

Yes, though results need confirmation. PMS disappeared completely in 37.4 percent. Duration dropped 2.6 days. Bloating decreased 60 percent. But there was no control group, so certainty is limited.

 Early or limited evidence

1473 women in France with PMS

## What they did

1473 women with PMS took Daflon 500 mg (2 tablets daily) for 3 menstrual cycles. Symptoms were tracked daily with a 24-item diary, plus weight and body measurements.

## What they found

PMS disappeared completely in 37.4 percent of women. Average duration decreased 2.6 days (p less than 0.0001). Congestion and bloating symptoms decreased about 60 percent. Weight gain decreased 29 percent.

## What it means for you

This flavonoid may help PMS bloating, especially for women with congestive symptoms. Limitation: open-label design and no control group means improvements might include placebo effect. Results need confirmation in controlled study.

37.4%

complete disappearance

2.6 days

shorter duration

60%

less bloating

## About the study

Original title [Premenstrual syndrome in France: epidemiology and therapeutic effectiveness of 1000 mg of micronized purified flavonoid fraction in 1473 gynecological patients] Authors Serfaty D, Magneron AC Journal Contraception, fertilite, sexualite (1992) Year 1997 Study design Non-randomised trial Participants 500 What was tested Daflon 500 mg at 2 tablets daily for 3 menstrual cycles Read the paper [https://pubmed.ncbi.nlm.nih.gov/9064059/](https://pubmed.ncbi.nlm.nih.gov/9064059/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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