---
title: Does a combination of natural products help reduce premenstrual syndrome symptoms?
description: Yes, a combination of calcium, vitamin D, and plant compounds (lycopene, astaxanthin, and citrus bioflavonoids) reduced PMS symptoms by 75% compared to placeb
url: https://niyora.com/research/papers/premenstrual-syndrome-pms-treatment-with-physiological-modulators-2020/
---

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- Does a combination of natural products help reduce premenstrual syndrome symptoms?

Study, 2020

# Does a combination of natural products help reduce premenstrual syndrome symptoms?

Yes, a combination of calcium, vitamin D, and plant compounds (lycopene, astaxanthin, and citrus bioflavonoids) reduced PMS symptoms by 75% compared to placebo, with individual symptoms reduced between 63% and 96%.

 Moderate study design

22 women with premenstrual syndrome

## What they did

22 women with PMS took either the supplement formula or a placebo pill twice a day, starting when symptoms appeared and continuing for the next 3 days. A 32-item symptom checklist was used to score symptoms before and after treatment.

## What they found

The supplement formula reduced the total PMS symptom score by 75%. Individual symptoms improved by 63% to 96%, with anxiety reduced by 63%, indecision reduced by 96%, and colic pain reduced by 83%.

## What it means for you

A combination of calcium, vitamin D, and plant compounds may help reduce PMS symptoms quickly when taken at the start of symptoms. However, this study was small (only 22 women) and did not provide details about how participants were assigned to treatment or placebo, so it is not clear how reliable the results are.

22

women in the study

75%

reduction in total symptom score

83%

reduction in colic pain

## About the study

Original title Premenstrual Syndrome (PMS) Treatment with Physiological Modulators Authors Umberto Cornelli, Hern, ez Santos et al. Journal Gynecology & Obstetrics Year 2020 Study design Study What was tested Formula containing calcium, vitamin D, lycopene, astaxanthin, citrus bioflavonoids vs placebo Open access Yes Read the paper [doi.org/10.35248/2161-10932.20.10.523](https://doi.org/10.35248/2161-10932.20.10.523)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Calcium](https://niyora.com/research/topics/treatment-calcium/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)

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Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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