--- title: Do women with PMS show different hormone patterns and ovulation timing after the corpus luteum is removed? description: Yes. Women with PMS took longer to ovulate after corpus luteum removal (21 days versus 19 days in controls) and had lower FSH levels, suggesting their hormona url: https://niyora.com/research/papers/prolonged-follicular-phase-and-depressed-gonadotrophins-following-hysterectomy-1985/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Do women with PMS show different hormone patterns and ovulation timing after the corpus luteum is removed? Case-control study, 1985 # Do women with PMS show different hormone patterns and ovulation timing after the corpus luteum is removed? Yes. Women with PMS took longer to ovulate after corpus luteum removal (21 days versus 19 days in controls) and had lower FSH levels, suggesting their hormonal feedback system is more sensitive. Early or limited evidence 7 women with PMS and 7 control women ## What they did 7 women with PMS and 7 control women underwent hysterectomy with removal of the corpus luteum during the middle of the luteal phase. Hormone levels were measured afterward to track ovulation timing. ## What they found Before surgery, women with PMS had lower progesterone and FSH but slightly higher estradiol. After corpus luteum removal, women with PMS took 21 days to ovulate (range 18-24) compared to 19 days in controls (range 14-20) (p<0.01). The FSH rise was delayed in PMS women and FSH levels were significantly lower during the late follicular phase, but estradiol levels did not differ between groups. ## What it means for you Women with PMS may have a more sensitive hormonal feedback system that suppresses FSH more than normal, even though estrogen levels are normal. This could be one biological cause of PMS. The study is very limited by its small sample size and the surgical nature of the intervention. 21 Days to ovulation in PMS women 19 Days to ovulation in controls 7 Women per group ## About the study Original title Prolonged follicular phase and depressed gonadotrophins following hysterectomy and corpus lute-ectomy in women with premenstrual tension syndrome Authors Bäckström T, Smith S, Lothian H et al. Journal Clinical endocrinology Year 1985 Study design Case-control study What was tested Removal of the corpus luteum during surgery Read the paper [doi.org/10.1111/j.1365-2265.1985.tb00162.x](https://doi.org/10.1111/j.1365-2265.1985.tb00162.x) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Surgical menopause](https://niyora.com/research/topics/treatment-surgery/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2018 Which women are most likely to experience hot flashes during menopause? Review, 2015 What do we know about PMS and PMDD and how are they treated? Cohort study, 2022 What are PMS and PMDD and how should they be diagnosed and treated? Review, 2012 Is depression linked to hormonal changes during the menstrual cycle, pregnancy, and menopause? Randomised trial, 2006 Do different types of PMS symptoms respond better to different medicines? Randomised trial, 1994 Does stopping ovulation help severe premenstrual tension? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗