--- title: Does telcagepant prevent migraines during the menstrual period? description: Telcagepant did not reduce overall monthly migraine days. However, it did reduce headaches on the days it was taken around the period. It was generally safe. url: https://niyora.com/research/papers/randomized-controlled-trial-of-the-cgrp-receptor-antagonist-telcagepant-for-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does telcagepant prevent migraines during the menstrual period? Randomised trial, 2016 # Does telcagepant prevent migraines during the menstrual period? Telcagepant did not reduce overall monthly migraine days. However, it did reduce headaches on the days it was taken around the period. It was generally safe. Strong study design 887 women with migraine for at least 3 months who experienced perimenstrual headaches ## What they did Women with migraine and perimenstrual headaches took either telcagepant 140 mg or placebo for 7 consecutive days around their period over a 6-month trial. Women needed to have at least 5 moderate or severe migraines per month before starting. ## What they found In 887 women studied, telcagepant did not significantly reduce mean monthly headache days (treatment difference minus 0.5 day). However, telcagepant did reduce perimenstrual headache days on the days the drug was taken (treatment difference minus 0.4 day). It was well tolerated with 2.5% discontinuing due to adverse events. ## What it means for you Telcagepant works when taken but does not change the overall number of migraines per month. Liver enzyme elevations occurred in 0.6% on telcagepant versus 0.4% on placebo. This is a large, well-designed study, but the main goal of reducing monthly migraines was not achieved. 887 Women in efficacy subset -0.5 day Monthly headache reduction with telcagepant 6 months Study duration ## About the study Original title Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine Authors Ho TW, Ho AP, Ge YJ et al. Journal Cephalalgia : an international journal of headache Year 2016 Study design Randomised trial Participants 887 What was tested Telcagepant 140 mg or placebo taken for 7 consecutive days around the menstrual period Open access Yes Read the paper [doi.org/10.1177/0333102415584308](https://doi.org/10.1177/0333102415584308) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Cohort study, 2022 Can women accurately tell if they have period-related migraines, or do they need to track them? Guideline, 2021 How should migraine be managed in women, particularly menstrual migraine? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Randomised trial, 2005 Does sumatriptan work for migraines around the menstrual cycle? Randomised trial, 2005 Are triptans effective for menstrual migraine? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗