---
title: Does synthetic diosmin help premenstrual breast pain? | Niyora
description: Yes, synthetic diosmin significantly reduced breast pain over one year and the improvement lasted. However, this study had no placebo group, so we cannot tell
url: https://niyora.com/research/papers/randomized-study-of-the-use-of-synthetic-diosmin-in-premenstrual-and-vascular-1990/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Does synthetic diosmin help premenstrual breast pain?

Randomised trial, 1990

# Does synthetic diosmin help premenstrual breast pain?

Yes, synthetic diosmin significantly reduced breast pain over one year and the improvement lasted. However, this study had no placebo group, so we cannot tell if the benefit is from the drug itself or other factors.

 Early or limited evidence

120 women with premenstrual and vascular breast pain; 120 untreated controls

## What they did

120 women with premenstrual and vascular breast pain received synthetic diosmin. Another 120 women were not treated (controls). Both groups were observed for one year to track changes in breast pain.

## What they found

Women treated with diosmin had a significant decrease in breast pain that was maintained throughout the year.

## What it means for you

Diosmin may help premenstrual breast pain, but the main limit is that there was no placebo group, so we cannot know if the improvement is from the drug itself or from attention, time, or expectation. The study also lacks details about how pain was measured.

120

Women treated

120

Control group

1 year

Duration

## About the study

Original title [Randomized study of the use of synthetic diosmin in premenstrual and vascular dysplastic mastodynia] Authors Meggiorini ML, Cascialli GL, Luciani S et al. Journal Minerva ginecologica Year 1990 Study design Randomised trial Participants 120 What was tested Synthetic diosmin for one year Read the paper [https://pubmed.ncbi.nlm.nih.gov/2290601/](https://pubmed.ncbi.nlm.nih.gov/2290601/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

Does vitamin D supplementation help PMS symptoms?

Systematic review, 2024

Does yoga help PMS symptoms?

Randomised trial, 2024

Does estetrol/drospirenone birth control improve PMS symptoms?

Systematic review, 2023

Does body composition affect premenstrual syndrome symptoms?

Randomised trial, 2023

Does zinc supplementation reduce PMS symptoms in women?

Systematic review, 2021

Does damask rose help reduce menstrual pain, headache, fatigue, anxiety, and bloating?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗