---
title: Do women with PMS have different ANP hormone levels during their cycle?
description: Yes. Women with PMS have consistently lower ANP levels throughout their cycle, especially during the luteal phase, while women without PMS show no cycle-relat
url: https://niyora.com/research/papers/reduced-atrial-natriuretic-peptide-concentrations-in-premenstrual-syndrome-1990/
---

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- Do women with PMS have different ANP hormone levels during their cycle?

Case-control study, 1990

# Do women with PMS have different ANP hormone levels during their cycle?

Yes. Women with PMS have consistently lower ANP levels throughout their cycle, especially during the luteal phase, while women without PMS show no cycle-related changes.

 Moderate study design

11 women with PMS and 12 without

## What they did

Case-control study measuring ANP hormone concentrations using radioimmunoassay in 11 women with PMS and 12 without across different menstrual cycle phases.

## What they found

Control women showed no change in ANP across the menstrual cycle. Women with PMS showed a significant drop in ANP in the mid-luteal phase compared to the follicular phase. Throughout the cycle, PMS women had lower ANP than controls, with statistically significant differences in the early, mid, and late luteal phases.

## What it means for you

Women with PMS may have a biological difference in a hormone involved in fluid and sodium regulation. The lower ANP levels might reflect changes in blood volume or body sodium. This was a small study looking at one specific hormone, so practical significance is unclear.

11

Women with PMS

12

Control women

## About the study

Original title Reduced atrial natriuretic peptide concentrations in premenstrual syndrome Authors Hussain SY, O'Brien PM, De Souza V et al. Journal British journal of obstetrics and gynaecology Year 1990 Study design Case-control study Participants 23 Read the paper [doi.org/10.1111/j.1471-0528.1990.tb01825.x](https://doi.org/10.1111/j.1471-0528.1990.tb01825.x)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)

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