--- title: Does the migraine drug ubrogepant work differently for period migraines than other migraines? description: No. In 734 women, ubrogepant worked about the same whether the migraine happened around the period or at other times. This is reliable information from a larg url: https://niyora.com/research/papers/safety-and-efficacy-of-ubrogepant-for-the-acute-treatment-of-perimenstrual-2023/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does the migraine drug ubrogepant work differently for period migraines than other migraines? Randomised trial, 2023 # Does the migraine drug ubrogepant work differently for period migraines than other migraines? No. In 734 women, ubrogepant worked about the same whether the migraine happened around the period or at other times. This is reliable information from a large study of an approved drug. Moderate study design 734 women from a migraine treatment trial who treated at least one migraine with ubrogepant ## What they did An analysis of 734 women from a large migraine drug trial who took ubrogepant (50 mg or 100 mg) to treat migraines. Researchers compared whether the drug worked differently for migraines that started 2 days before or during the first 3 days of the period versus migraines at other times. They measured complete pain relief (pain freedom) at 2 hours. ## What they found Period migraines: 28.7% achieved complete pain relief at 2 hours with 50 mg, and 29.7% with 100 mg. Non-period migraines: 22.1% with 50 mg and 25.3% with 100 mg. These differences were not statistically significant. Partial pain relief was similar: 64-68% for both types. ## What it means for you Ubrogepant works about the same for period-related migraines as other migraines. However, complete pain relief only happens in about 28-30% of women, which is modest. This analysis was done after the main trial finished, so it was not the original research question. 734 women analyzed 28.7% pain freedom at 2h for period migraine (50 mg) 22.1% pain freedom at 2h for non-period migraine (50 mg) ## About the study Original title Safety and efficacy of ubrogepant for the acute treatment of perimenstrual migraine attacks: A post hoc analysis Authors MacGregor EA, Hutchinson S, Lai H et al. Journal Headache Year 2023 Study design Randomised trial Participants 734 What was tested Ubrogepant 50 mg or 100 mg taken when a migraine started Open access Yes Read the paper [doi.org/10.1111/head.14619](https://doi.org/10.1111/head.14619) ## Topics [Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Cohort study, 2022 Can women accurately tell if they have period-related migraines, or do they need to track them? Guideline, 2021 How should migraine be managed in women, particularly menstrual migraine? Randomised trial, 2016 Does telcagepant prevent migraines during the menstrual period? Randomised trial, 2014 Does the combination of sumatriptan and naproxen sodium reduce menstrual symptoms and migraine? Randomised trial, 2005 Does sumatriptan work for migraines around the menstrual cycle? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗