--- title: Does a multinutrient supplement reduce premenstrual and menstrual symptoms? description: The supplement appears to reduce symptom severity and duration, with 88% of women reporting reduced symptom severity by the third cycle. However, this pilot s url: https://niyora.com/research/papers/self-reported-changes-in-premenstrual-and-menstrual-symptoms-among-females-2026/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does a multinutrient supplement reduce premenstrual and menstrual symptoms? Randomised trial, 2026 # Does a multinutrient supplement reduce premenstrual and menstrual symptoms? The supplement appears to reduce symptom severity and duration, with 88% of women reporting reduced symptom severity by the third cycle. However, this pilot study lacked a placebo control group, so we cannot be certain the supplement itself caused the improvement. Early or limited evidence 40 women with average age 33 with premenstrual and menstrual symptoms ## What they did 40 women with an average age of 33 years took a daily supplement containing saffron extract, chamomile extract, minerals (chromium, magnesium, zinc, iron), vitamins (D, B6, C), and omega-3 fatty acids for three consecutive menstrual cycles. Symptoms were measured at baseline and after each cycle using a validated questionnaire. ## What they found Symptom scores decreased significantly from baseline to cycle 1, cycle 2, and cycle 3 (p<0.0001). By cycle 3, 88% of women agreed the supplement reduced symptom severity and 82% agreed it reduced symptom duration. ## What it means for you The supplement may help with menstrual symptoms. However, this was a small pilot study without a placebo control group, so we cannot rule out placebo effect or natural variation in symptoms. Larger placebo-controlled trials are needed. 40 women 3 menstrual cycles 88% agreed symptoms reduced by cycle 3 ## About the study Original title Self-Reported Changes in Premenstrual and Menstrual Symptoms among Females Taking a Novel Multinutrient Supplement: A Pilot Study Authors Smith M, Mitschke S, van der Schoot A Journal Current developments in nutrition Year 2026 Study design Randomised trial What was tested Novel multinutrient supplement containing saffron, chamomile, minerals, vitamins, and omega-3 for three cycles Open access Yes Read the paper [doi.org/10.1016/j.cdnut.2026.109511](https://doi.org/10.1016/j.cdnut.2026.109511) Original abstract Background: Premenstrual and menstrual symptoms arise in response to cyclical hormonal fluctuations and encompass psychological and physical manifestations that may significantly impair quality of life. Treatment options are limited, demonstrate inconsistent efficacy, and are associated with notable adverse effects. There is growing interest in evidence-based nutritional approaches, with several placebo-controlled trials demonstrating that certain nutrient supplements significantly alleviate menstrual-cycle-related symptomatology. Objectives: This single-arm pilot study aims to evaluate self-reported changes in premenstrual and menstrual symptoms in females taking a novel multinutrient supplement containing saffron extract, chamomile extract, essential minerals (chromium, magnesium, zinc, iron), vitamins (D, B6, C), and- omega-3 (n-3) fatty acids, using advanced encapsulation technology. Methods: Forty females (mean age: 33 y) with premenstrual and menstrual symptoms consumed the supplement daily for 3 consecutive menstrual cycles. The validated Menstrual Symptom Questionnaire (MSQ) and a 5-point severity rating scale evaluated symptoms at baseline and after each menstrual cycle. Results: Overall MSQ scores decreased significantly from baseline to cycle 1 ( P = 0.0028), cycle 2 ( P P P P < 0.0001). By cycle 3, 88% of participants agreed that the supplement reduced symptom severity, and 82% agreed that the supplement reduced symptom duration. Conclusions: These findings suggest that this novel multinutrient supplement may be of interest as a nutritional approach to support females throughout the menstrual cycle, warranting further investigation in randomized, placebo-controlled trials.This trial was registered on clinicaltrials.gov as NCT07267728. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Diet and nutrition](https://niyora.com/research/topics/treatment-diet/)[Magnesium](https://niyora.com/research/topics/treatment-magnesium/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Saffron](https://niyora.com/research/topics/treatment-saffron/)[Omega-3 fatty acids](https://niyora.com/research/topics/treatment-omega-3/)[Zinc and iron](https://niyora.com/research/topics/treatment-zinc-iron/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2023 Can herbs and supplements help with PMS symptoms? Review, 2025 Does nutrition affect PMS and menstrual cycle regularity? Systematic review, 2025 Do nutritional interventions help with emotional symptoms of PMS? Systematic review, 2009 Which herbs, vitamins and minerals help treat PMS? Review, 2026 Can diet and nutrition help reduce PMS symptoms? Survey study, 2023 Can diet help reduce PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗