---
title: Does a genetic variant in the serotonin receptor gene affect PMDD risk?
description: A genetic variant (the C version) was more common in women with PMDD. Having at least one C version was associated with increased PMDD risk, though evidence w
url: https://niyora.com/research/papers/serotonin-receptor-1a-c-1019-g-polymorphism-associated-with-premenstrual-2007/
---

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- Does a genetic variant in the serotonin receptor gene affect PMDD risk?

Case-control study, 2007

# Does a genetic variant in the serotonin receptor gene affect PMDD risk?

A genetic variant (the C version) was more common in women with PMDD. Having at least one C version was associated with increased PMDD risk, though evidence was borderline.

 Early or limited evidence

53 women with PMDD (average age 37.7 years) and 51 healthy controls (average age 36.2 years)

## What they did

Researchers examined a specific genetic variation in 53 women with PMDD (average age 37.7 years) and 51 healthy controls (average age 36.2 years), comparing which genetic versions they carried.

## What they found

The C/C genetic version was much more common in PMDD patients than controls. Having at least one C allele appeared to increase the risk of PMDD, though this finding was borderline.

## What it means for you

A genetic variant may increase PMDD risk, though the finding was borderline and opposite to expectations. This small study needs confirmation in larger groups.

53

Women with PMDD

51

Healthy control women

37.7 years

Average age of PMDD group

## About the study

Original title Serotonin receptor 1A C(-1019)G polymorphism associated with premenstrual dysphoric disorder Authors Dhingra V, Magnay JL, O'Brien PM et al. Journal Obstetrics and gynecology Year 2007 Study design Case-control study Participants 53 What was tested None; observational genetic comparison study Read the paper [doi.org/10.1097/01.aog.0000284448.73490.ac](https://doi.org/10.1097/01.aog.0000284448.73490.ac)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)

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## Related studies

Cohort study, 2026

What genetic factors are linked to premenstrual symptoms?

Systematic review, 2026

How often do mood disorders and PMS or PMDD occur together?

Systematic review, 2026

Does vitamin D supplementation help PMS symptoms?

Study, 2026

How do women with PMDD process emotions differently in their brains?

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Systematic review, 2026

How much of PMDD treatment improvement comes from placebo effect?

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