--- title: Does menstrual cycle phase affect how women with asthma respond to anti-inflammatory medication? description: Yes. Women with premenstrual asthma had acute reactions to meclofenamate during the early cycle phase but never during the late cycle phase. Prostaglandin lev url: https://niyora.com/research/papers/serum-13-14-dioh-15-keto-prostaglandin-f2-alpha-and-airway-response-to-1986/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does menstrual cycle phase affect how women with asthma respond to anti-inflammatory medication? Randomised trial, 1986 # Does menstrual cycle phase affect how women with asthma respond to anti-inflammatory medication? Yes. Women with premenstrual asthma had acute reactions to meclofenamate during the early cycle phase but never during the late cycle phase. Prostaglandin levels were 10 times higher in the early phase. Early or limited evidence 24 women with premenstrual asthma, 4 with regular asthma, 4 healthy women ## What they did Researchers measured prostaglandin levels and airway response to meclofenamate and metaproterenol at two cycle phases in 24 women with premenstrual asthma, 4 with regular asthma, and 4 healthy women. Each woman received a single 100 mg dose of meclofenamate and 1.5 mg of metaproterenol during the early (follicular) and late (luteal) cycle phases. ## What they found Prostaglandin averaged 140.9 pg/0.1 ml in the follicular phase but only 14.4 pg/0.1 ml in the luteal phase. Six women with premenstrual asthma had acute reactions to meclofenamate during the follicular phase but never during the luteal phase. These reactions occurred more often in women on corticosteroids. One woman had 18% improvement in lung function with meclofenamate during the luteal phase. ## What it means for you Women with premenstrual asthma may experience worse reactions to meclofenamate during the early menstrual cycle phase. This may be related to lower prostaglandin levels during the late cycle. However, this finding applies to only one medication and may be specific to women taking corticosteroids. 140.9 pg/0.1 ml Prostaglandin in follicular phase 14.4 pg/0.1 ml Prostaglandin in luteal phase 6 of 24 Women with premenstrual asthma with reactions to meclofenamate ## About the study Original title Serum 13-14-diOH-15-keto-prostaglandin F2 alpha and airway response to meclofenamate and metaproterenol in relation to the menstrual cycle Authors Eliasson O, Longo M, Dore-Duffy P et al. Journal The Journal of asthma : official journal of the Association for the Care of Asthma Year 1986 Study design Randomised trial Participants 24 What was tested Single dose of 100 mg oral meclofenamate and 1.5 mg inhaled metaproterenol at follicular and luteal cycle phases Read the paper [doi.org/10.3109/02770908609073178](https://doi.org/10.3109/02770908609073178) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Economic burden](https://niyora.com/research/topics/life-area-economic-burden/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Guideline, 2023 How are GnRH agonists used to treat PMDD that doesn't respond to standard medications? Randomised trial, 2009 Does longer sertraline treatment prevent PMS symptoms from returning? Review, 2005 Do antidepressants improve quality of life in women with PMDD? Randomised trial, 1997 Does tamoxifen or danazol help severe cyclical breast pain? Review, 2026 How much do PMS and menstrual disorders affect women's work, school, and quality of life? Case-control study, 2026 Does vitamin D help PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗