---
title: Is sex hormone-binding globulin (SHBG) different in women with severe PMS?
description: Yes. Women with severe PMS have significantly lower SHBG binding capacity. This suggests low SHBG may help explain PMS and could be useful for diagnosis.
url: https://niyora.com/research/papers/sex-hormone-binding-globulin-concentrations-in-women-with-severe-premenstrual-1981/
---

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- Is sex hormone-binding globulin (SHBG) different in women with severe PMS?

Case-control study, 1981

# Is sex hormone-binding globulin (SHBG) different in women with severe PMS?

Yes. Women with severe PMS have significantly lower SHBG binding capacity. This suggests low SHBG may help explain PMS and could be useful for diagnosis.

 Moderate study design

50 women with severe PMS, 50 age-matched control women

## What they did

Case-control study measuring SHBG binding capacity in 50 women with severe PMS and 50 age-matched control women.

## What they found

Women with severe PMS had significantly lower SHBG binding capacity compared to controls.

## What it means for you

Low SHBG may help explain what causes PMS and could be used as a diagnostic test. However, this is a single study and needs to be repeated in larger groups of women.

50

women with severe PMS

50

age-matched control women

P = 0.001

difference was statistically significant

## About the study

Original title Sex hormone-binding globulin concentrations in women with severe premenstrual syndrome Authors Dalton ME Journal Postgraduate medical journal Year 1981 Study design Case-control study Participants 50 Open access Yes Read the paper [doi.org/10.1136/pgmj.57.671.560](https://doi.org/10.1136/pgmj.57.671.560)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)

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