---
title: Are SSRIs like fluoxetine effective for PMDD? | Niyora
description: Fluoxetine is licensed for PMDD treatment and there is evidence that SSRIs work for this condition, though not for all women.
url: https://niyora.com/research/papers/ssris-for-premenstrual-dysphoric-disorder-2002/
---

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- Are SSRIs like fluoxetine effective for PMDD?

Review, 2002

# Are SSRIs like fluoxetine effective for PMDD?

Fluoxetine is licensed for PMDD treatment and there is evidence that SSRIs work for this condition, though not for all women.

 Early or limited evidence

Women with PMDD

## What they did

A review of the evidence for SSRI effectiveness in PMDD, including discussion of diagnosis and treatment with fluoxetine and other SSRIs.

## What they found

The review presents evidence for the efficacy of fluoxetine and other SSRIs in treating PMDD. Fluoxetine is licensed in the UK for this purpose.

## What it means for you

SSRIs are an established treatment option for PMDD, with fluoxetine being officially approved. The full evidence of how well they work requires reading the primary studies.

2-10%

of women with severe PMS

## About the study

Original title SSRIs for premenstrual dysphoric disorder Journal Drug and therapeutics bulletin Year 2002 Study design Review What was tested SSRIs, particularly fluoxetine Read the paper [doi.org/10.1136/dtb.2002.40970](https://doi.org/10.1136/dtb.2002.40970)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2024

What are the best treatments for PMDD and PMS?

Review, 2024

What are the most effective treatments for PMDD?

Systematic review, 2024

Do SSRI antidepressants help treat PMS and PMDD?

Randomised trial, 2023

Does taking sertraline when PMDD symptoms start improve how well women function?

Guideline, 2023

How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

Review, 2022

What causes severe PMS and what treatments work?

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