---
title: Can sensitivity to your own hormones cause PMS? | Niyora
description: Yes. Some women may have unusual sensitivity to estrogen and progesterone that causes PMS and other problems. This can be diagnosed with skin tests and treate
url: https://niyora.com/research/papers/steroid-hormone-hypersensitivity-clinical-presentation-and-management-2011/
---

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- Can sensitivity to your own hormones cause PMS?

Study, 2011

# Can sensitivity to your own hormones cause PMS?

Yes. Some women may have unusual sensitivity to estrogen and progesterone that causes PMS and other problems. This can be diagnosed with skin tests and treated with small hormone doses.

 Early or limited evidence

Not applicable - clinical overview, not a study

## What they did

This is a clinical explanation of hormone sensitivity, not a research study with specific participants.

## What they found

Hypersensitivity to estrogens and progestogens can cause premenstrual syndrome, painful periods, and fertility problems. Diagnosis is confirmed by skin testing for inflammatory responses to small hormone doses. Treatment involves desensitization with small hormone doses.

## What it means for you

If you have PMS, one possible cause could be hormone sensitivity. A skin test could diagnose it. However, this is a clinical opinion, not evidence from a research study.

## About the study

Original title Steroid hormone hypersensitivity: clinical presentation and management Authors Itsekson AM, Seidman DS, Zolti M et al. Journal Fertility and sterility Year 2011 Study design Study What was tested Hormone desensitization therapy Open access Yes Read the paper [doi.org/10.1016/j.fertnstert.2011.05.025](https://doi.org/10.1016/j.fertnstert.2011.05.025)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Dysmenorrhea and period pain](https://niyora.com/research/topics/condition-dysmenorrhea/)[Pregnancy and postpartum](https://niyora.com/research/topics/comorbidity-postpartum/)

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