---
title: What's the best way to extract Yueanjian herb to treat PMS? | Niyora
description: Steam-distillation produced the best results in rats with PMS symptoms, based on hormone and behavior changes. However, this was tested in rats, not in women,
url: https://niyora.com/research/papers/study-on-preparation-method-of-yueanjian-for-treatmen-of-premenstrual-syndrome-2012/
---

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- What's the best way to extract Yueanjian herb to treat PMS?

Lab study, 2012

# What's the best way to extract Yueanjian herb to treat PMS?

Steam-distillation produced the best results in rats with PMS symptoms, based on hormone and behavior changes. However, this was tested in rats, not in women, so it's unclear how it would work in people.

 Early or limited evidence

Laboratory rats with an artificially created PMS-like syndrome

## What they did

Researchers created a PMS-like condition in rats using stress. They treated the rats with Yueanjian herb extracted three different ways: water extraction, steam-distillation, and alcohol extraction. They measured hormones and behavior in all three groups.

## What they found

Both steam-distilled and alcohol-extracted versions increased estradiol and progesterone (hormones that change through the cycle). The steam-distilled group showed much better behavior scores in an open-field test. The steam-distilled version also contained more salvianolic acid B, an active ingredient in the herb.

## What it means for you

Steam-distillation may be the best way to prepare Yueanjian for treating PMS. The main limitation is that this was tested in rats, not women, so we don't know if these findings translate to actual PMS treatment in people.

3

Extraction methods tested

2

Hormones measured

## About the study

Original title [Study on preparation method of Yueanjian for treatmen of premenstrual syndrome] Authors Li X, Gan Y, Zhang H et al. Journal Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica Year 2012 Study design Lab study What was tested Three different extraction methods of Yueanjian herb Read the paper [https://pubmed.ncbi.nlm.nih.gov/22792790/](https://pubmed.ncbi.nlm.nih.gov/22792790/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Alcohol, smoking and substance use](https://niyora.com/research/topics/comorbidity-substance-use/)

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