---
title: Could how progesterone receptors work explain PMS? | Niyora
description: Researchers proposed that PMS might be caused by how progesterone receptors transport progesterone into cells. This could explain why blood tests for progeste
url: https://niyora.com/research/papers/the-aetiology-of-premenstrual-syndrome-is-with-the-progesterone-receptors-1990/
---

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- Could how progesterone receptors work explain PMS?

Study, 1990

# Could how progesterone receptors work explain PMS?

Researchers proposed that PMS might be caused by how progesterone receptors transport progesterone into cells. This could explain why blood tests for progesterone don't help diagnose PMS and why high doses are needed for treatment.

 Early or limited evidence

No people studied - this is a theoretical paper based on molecular biology research

## What they did

This was not a study with people. Instead, researchers looked at recent discoveries about how progesterone receptors work and proposed a theory about what might cause PMS.

## What they found

They suggest PMS relates to how progesterone receptors transport progesterone into cells during the reproductive years.

## What it means for you

This is a theory, not proven by testing in women. It is an idea from cell biology research that could help explain why PMS happens and why some treatments fail. It has not been tested in people yet.

## About the study

Original title The aetiology of premenstrual syndrome is with the progesterone receptors Authors Dalton K Journal Medical hypotheses Year 1990 Study design Study What was tested None - theoretical paper Read the paper [doi.org/10.1016/0306-9877(90)90026-b](https://doi.org/10.1016/0306-9877(90)90026-b)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)

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