---
title: Does dydrogesterone or pyridoxine work better for premenstrual syndrome?
description: Dydrogesterone worked for 70% of women with premenstrual syndrome, while pyridoxine worked for 55%. At least 3 months of treatment is needed to see if either
url: https://niyora.com/research/papers/the-clinician-s-view-of-patients-with-premenstrual-syndrome-1979/
---

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- Does dydrogesterone or pyridoxine work better for premenstrual syndrome?

Study, 1979

# Does dydrogesterone or pyridoxine work better for premenstrual syndrome?

Dydrogesterone worked for 70% of women with premenstrual syndrome, while pyridoxine worked for 55%. At least 3 months of treatment is needed to see if either helps.

 Moderate study design

500 women with premenstrual syndrome (part of a larger group of 2000 studied over 5 years)

## What they did

Researchers treated 500 women with premenstrual syndrome over 5 years as part of a larger study of 2000 women. Women received either dydrogesterone (10 mg twice daily from day 12 to day 26 of the cycle), pyridoxine (40 mg twice daily), or in some cases spironolactone, bromocriptine, or MAOIs. Researchers tracked whether women were cured or greatly relieved of their symptoms.

## What they found

Dydrogesterone produced an overall response rate of 70%, meaning 70% of women were cured or greatly relieved. Pyridoxine had an overall response of 55%. Some women who did not respond to dydrogesterone benefitted greatly from pyridoxine.

## What it means for you

Dydrogesterone appears more effective overall, especially for fluid retention and depression. Pyridoxine may work better for breast discomfort. This was observational rather than a controlled comparison, so we cannot be certain which is truly better. At least 3 months of treatment is needed to assess effectiveness.

70%

women greatly relieved or cured with dydrogesterone

55%

women greatly relieved or cured with pyridoxine

500

women treated in this analysis

## About the study

Original title The clinician's view of patients with premenstrual syndrome Authors RONALD W. TAYLOR, C. E. James Journal Current Medical Research and Opinion Year 1979 Study design Study Participants 500 What was tested Dydrogesterone, pyridoxine, spironolactone, bromocriptine, or MAOIs Read the paper [doi.org/10.1185/03007997909110098](https://doi.org/10.1185/03007997909110098)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

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Randomised trial, 2003

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