--- title: Does supplementing progesterone during the luteal phase increase progesterone levels? description: Yes, both dydrogesterone alone and dydrogesterone with HCG injections increased progesterone in the middle of the luteal phase compared to placebo. However, p url: https://niyora.com/research/papers/the-effect-of-various-methods-of-luteal-phase-supplementation-on-serum-1998/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does supplementing progesterone during the luteal phase increase progesterone levels? Randomised trial, 1998 # Does supplementing progesterone during the luteal phase increase progesterone levels? Yes, both dydrogesterone alone and dydrogesterone with HCG injections increased progesterone in the middle of the luteal phase compared to placebo. However, progesterone returned to placebo levels by day 11 and did not affect the premenstrual period if pregnancy did not occur. Moderate study design 56 infertile women with short luteal phase ## What they did Randomized, placebo-controlled study of 56 infertile women with a short luteal phase (less than 11 days). Women received either 10 mg dydrogesterone twice daily, or 10 mg dydrogesterone twice daily plus HCG injections, or placebo from corpus luteum detection until menstruation. Progesterone levels were measured on days 3, 7, and 11. ## What they found On day 7 (midluteal phase), both treatment groups had significantly higher progesterone than placebo. The dydrogesterone plus HCG group had higher progesterone than dydrogesterone alone. By day 11, progesterone in both treatment groups had dropped to levels comparable with placebo. ## What it means for you These methods can briefly increase progesterone around implantation but do not affect the premenstrual period if pregnancy does not occur. The study was small and specific to infertile women with documented short luteal phase, so findings may not apply to PMS. 56 Participants 10 mg x2/day Dydrogesterone dose 1500 IU / 4d HCG injection dose ## About the study Original title [The effect of various methods of luteal phase supplementation on serum progesterone level] Authors Jakiel G, Bokiniec M, Bakalczuk S et al. Journal Ginekologia polska Year 1998 Study design Randomised trial Participants 56 What was tested Dydrogesterone (10 mg twice daily) with or without HCG injections (1500 IU every 4 days) Read the paper [https://pubmed.ncbi.nlm.nih.gov/10224805/](https://pubmed.ncbi.nlm.nih.gov/10224805/) ## Topics [Cognition, concentration and memory](https://niyora.com/research/topics/symptom-cognition/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2014 Do estrogen and progesterone change how the brain processes emotions and decisions? Non-randomised trial, 2025 What treatments help PMS and PMDD? Review, 2025 How does progesterone affect mood and brain function? Randomised trial, 2006 Do women with PMDD and depression process progesterone differently than others? Study, 2003 Does cognitive behavioral therapy help premenstrual symptoms as well as medication? Randomised trial, 2003 Does leptin explain why women develop PMS symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗