---
title: Does vitamin B6 (pyridoxine) help with premenstrual syndrome symptoms?
description: This question cannot be answered here: the title refers to a trial of vitamin B6 for PMS, but the abstract text supplied is actually about the chemistry of br
url: https://niyora.com/research/papers/the-evaluation-of-the-effectiveness-of-pyridoxine-vitamin-b6-for-the-treatment-2009/
---

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- Does vitamin B6 (pyridoxine) help with premenstrual syndrome symptoms?

Randomised trial, 2009

# Does vitamin B6 (pyridoxine) help with premenstrual syndrome symptoms?

This question cannot be answered here: the title refers to a trial of vitamin B6 for PMS, but the abstract text supplied is actually about the chemistry of breaking down dextran (a sugar polymer) using ultrasound, with no mention of vitamin B6, PMS or any women at all.

 Early or limited evidence

Not applicable: the abstract describes laboratory dextran samples, not a human PMS study

## What they did

The abstract describes a lab chemistry experiment: six dextran samples of different starting molecular weights were broken down using ultrasound, and their molecular weight was tracked over time with a lab technique (HPGPC). This is not a study of people, vitamin B6 or PMS.

## What they found

As ultrasonic treatment continued, the dextran samples' average molecular weight and spread of molecular weights (polydispersity) decreased. Higher starting molecular weight samples broke down more, especially early on. A mathematical model (Malhotra model) fit the molecular weight data well, and a 'midpoint scission' model best matched how the dextran chains broke, with a strong statistical fit (R2 > 0.99).

## What it means for you

Because the abstract text does not match its title, there is no usable information here about vitamin B6 or PMS. This looks like a data mix-up, so no practical takeaway for PMS can be drawn from it.

6

dextran samples tested

>0.99

model fit (R2)

## About the study

Original title The Evaluation of the Effectiveness of Pyridoxine (Vitamin B6) for the Treatment of Premenstrual Syndrome: A Double Blind Randomized Clinical Trial Authors Maryam Kashanian, Maryam Kashanian, Robabeh Mazinani et al. Journal Journal of Nutrition Education and Behavior Year 2009 Study design Randomised trial What was tested None relevant to PMS; the abstract describes ultrasonic treatment of dextran in a lab Read the paper [doi.org/10.1016/j.jneb.2009.03.006](https://doi.org/10.1016/j.jneb.2009.03.006)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Vitamin B6](https://niyora.com/research/topics/treatment-vitamin-b6/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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