---
title: Do different doses of medroxyprogesterone affect mood in women on hormone replacement therapy?
description: Both doses caused mood symptoms, but the higher dose improved mood in women with a prior PMS history. This small randomized trial suggests lower doses do not
url: https://niyora.com/research/papers/the-impact-of-different-doses-of-medroxyprogesterone-acetate-on-mood-symptoms-in-2002/
---

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- Do different doses of medroxyprogesterone affect mood in women on hormone replacement therapy?

Randomised trial, 2002

# Do different doses of medroxyprogesterone affect mood in women on hormone replacement therapy?

Both doses caused mood symptoms, but the higher dose improved mood in women with a prior PMS history. This small randomized trial suggests lower doses do not help.

 Moderate study design

36 postmenopausal women in northern Sweden, some with a history of PMS

## What they did

A randomized double-blind crossover study of 36 postmenopausal women in northern Sweden. Women received 2 mg estradiol continuously and either 10 mg or 20 mg medroxyprogesterone acetate for 12 days of each cycle, for 5 cycles. Mood and physical symptoms were tracked daily.

## What they found

Physical symptoms did not differ between doses. Both groups had more negative mood with the 10 mg dose. Women with previous PMS had better positive mood with the 20 mg dose.

## What it means for you

In women on hormone replacement therapy, the higher dose of this progestin may be better for mood, especially if you have a PMS history. The study was small and included only postmenopausal women in Sweden.

36

Number of women

10 mg and 20 mg

Medroxyprogesterone doses tested

5 cycles

Treatment duration (28 days per cycle)

## About the study

Original title The impact of different doses of medroxyprogesterone acetate on mood symptoms in sequential hormonal therapy Authors Björn I, Bixo M, Nöjd KS et al. Journal Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology Year 2002 Study design Randomised trial Participants 36 What was tested Medroxyprogesterone acetate at 10 mg or 20 mg doses Read the paper [doi.org/10.1080/gye.16.1.1.8](https://doi.org/10.1080/gye.16.1.1.8)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

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