---
title: Does serotonin dysfunction play a role in PMDD? | Niyora
description: Evidence suggests serotonin dysfunction is involved in PMDD. Medications that increase serotonin, particularly fluoxetine, help reduce PMDD symptoms and have
url: https://niyora.com/research/papers/the-role-of-central-serotonergic-dysfunction-in-the-aetiology-of-premenstrual-2001/
---

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- Does serotonin dysfunction play a role in PMDD?

Review, 2001

# Does serotonin dysfunction play a role in PMDD?

Evidence suggests serotonin dysfunction is involved in PMDD. Medications that increase serotonin, particularly fluoxetine, help reduce PMDD symptoms and have been approved by the US Food and Drug Administration for this purpose.

 Moderate study design

Review of existing research (not a study of specific individuals)

## What they did

Reviewed existing research studies on how serotonin relates to PMDD and how treatments that affect serotonin work.

## What they found

Most evidence points to serotonin dysfunction in PMDD. Treatments that enhance serotonin are helpful in reducing symptoms. Fluoxetine, a medication that increases serotonin, has been approved by the US Food and Drug Administration for PMDD.

## What it means for you

Serotonin dysfunction appears to play a key role in PMDD, which is why serotonin-increasing medications can help. This conclusion is based on a review of existing studies rather than new research findings.

## About the study

Original title The role of central serotonergic dysfunction in the aetiology of premenstrual dysphoric disorder: therapeutic implications Authors Parry BL Journal CNS drugs Year 2001 Study design Review What was tested None - review article Read the paper [doi.org/10.2165/00023210-200115040-00003](https://doi.org/10.2165/00023210-200115040-00003)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)

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