---
title: Do different types of progestogen cause different types of symptoms?
description: Yes. Norethisterone causes more pain symptoms but fewer mood problems, while medroxyprogesterone and dydrogesterone show the opposite pattern.
url: https://niyora.com/research/papers/the-symptomatology-of-progestogen-intolerance-1994/
---

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- Do different types of progestogen cause different types of symptoms?

Survey study, 1994

# Do different types of progestogen cause different types of symptoms?

Yes. Norethisterone causes more pain symptoms but fewer mood problems, while medroxyprogesterone and dydrogesterone show the opposite pattern.

 Early or limited evidence

Women receiving oestrogen replacement therapy

## What they did

Cross-sectional study of women taking hormone replacement therapy with cyclical progestogen. Symptoms were assessed using a standardized questionnaire.

## What they found

Different progestogens caused different symptom patterns. Norethisterone was more likely to cause pain, while medroxyprogesterone and dydrogesterone were less likely to cause pain but more likely to cause mood and behavioral changes.

## What it means for you

The type of progestogen a woman takes affects which symptoms she experiences. However, this was an observational study without a control group, so we cannot be certain the drug type caused the symptom differences.

## About the study

Original title The symptomatology of progestogen intolerance Authors Smith RN, Holland EF, Studd JW Journal Maturitas Year 1994 Study design Survey study What was tested Exposure to different types of progestogen Read the paper [doi.org/10.1016/0378-5122(94)90046-9](https://doi.org/10.1016/0378-5122(94)90046-9)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

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