---
title: Does dydrogesterone help premenstrual tension symptoms? | Niyora
description: Yes, over 70% of women reported cure or marked improvement. Fluid retention improved almost completely, but mental symptoms and breast pain improved less. Thi
url: https://niyora.com/research/papers/the-treatment-of-premenstrual-tension-with-dydrogesterone-duphaston-1977/
---

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- Does dydrogesterone help premenstrual tension symptoms?

Randomised trial, 1977

# Does dydrogesterone help premenstrual tension symptoms?

Yes, over 70% of women reported cure or marked improvement. Fluid retention improved almost completely, but mental symptoms and breast pain improved less. This was early evidence needing confirmation with a controlled study.

 Early or limited evidence

50 women with premenstrual tension and lower than normal luteal phase progesterone

## What they did

Preliminary study in 50 women with lower than normal luteal phase progesterone. Dydrogesterone 10 mg twice daily was given from day 12 to day 26 of the menstrual cycle for at least 2 cycles.

## What they found

Over 70% of women reported cure or marked overall improvement. Fluid retention symptoms were almost universally cured. Mental symptoms were greatly improved but not always completely relieved. Breast discomfort was rarely relieved. No side effects reported.

## What it means for you

Dydrogesterone may help premenstrual symptoms, especially water retention, but this had no placebo control group, so we cannot be sure how much improvement was due to the drug versus expectation. Mental symptoms and breast pain may respond less well.

50

women studied

70%

had cure or marked improvement

10

mg twice daily dose

## About the study

Original title The treatment of premenstrual tension with dydrogesterone (‘Duphaston’) Authors RONALD W. TAYLOR Journal Current Medical Research and Opinion Year 1977 Study design Randomised trial Participants 50 What was tested Dydrogesterone 10 mg twice daily from day 12 to day 26 of menstrual cycle Read the paper [doi.org/10.1185/03007997709115299](https://doi.org/10.1185/03007997709115299)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

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