--- title: Does stopping ovulation with buserelin help PMS? | Niyora description: For some women yes, but for others it makes things much worse. Half improved with lasting symptom relief for 5 to 15 months, while half had severe side effect url: https://niyora.com/research/papers/the-use-of-an-lhrh-agonist-buserelin-in-the-long-term-management-of-premenstrual-1987/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does stopping ovulation with buserelin help PMS? Study, 1987 # Does stopping ovulation with buserelin help PMS? For some women yes, but for others it makes things much worse. Half improved with lasting symptom relief for 5 to 15 months, while half had severe side effects and stopped within 2 months. Early or limited evidence 20 women with premenstrual syndrome ## What they did Researchers gave 20 women with PMS a nasal spray called buserelin that stops the pituitary gland from signalling ovulation. They tracked symptom changes and side effects over time. ## What they found 10 women benefited and continued treatment for periods varying from 5 to 15 months, with significant improvements in mood and physical symptoms and mild side effects such as hot flushes. The remaining 10 women were made worse by the spray and stopped it within 2 months, sometimes with severe adverse effects. Of the long-term group, 6 eventually became amenorrhoeic (stopped menstruating) and 4 continued to menstruate. In women who continued, mood changes lost their relationship to menstruation but physical symptoms continued to appear before any menstrual bleeding. ## What it means for you Buserelin can help some women with PMS significantly, but it makes others much worse and it is not clear in advance which women will benefit. Even in women it helps, some physical symptoms may persist. The main limits are half had bad reactions, it was not compared to a control group, and individual characteristics that predict response are unknown. 20 women in study 10 women who improved 10 women who worsened ## About the study Original title The use of an LHRH agonist, buserelin, in the long-term management of premenstrual syndromes Authors Bancroft J, Boyle H, Warner P et al. Journal Clinical endocrinology Year 1987 Study design Study Participants 20 Read the paper [doi.org/10.1111/j.1365-2265.1987.tb01142.x](https://doi.org/10.1111/j.1365-2265.1987.tb01142.x) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Menstrual cycle and mood](https://niyora.com/research/topics/condition-cycle-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Systematic review, 2024 What are the best treatments for PMDD and PMS? Systematic review, 2023 What hormonal treatments have been tested for PMDD, menstrual migraine, and catamenial epilepsy? Systematic review, 2022 What are the best treatments for PMDD and PMS? Review, 2015 What do we know about PMS and PMDD and how are they treated? Review, 2008 What medications are FDA-approved for treating PMDD? Study, 2026 What treatments work for PMDD? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗