---
title: What treatments have been developed for PMS and PMDD? | Niyora
description: Over 40 years, hundreds of compounds have been patented for PMS and PMDD, including hormone therapies, antidepressants, vitamins, minerals, supplements, and n
url: https://niyora.com/research/papers/therapeutic-patents-for-the-treatment-of-premenstrual-syndrome-and-premenstrual-2003/
---

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- What treatments have been developed for PMS and PMDD?

Review, 2003

# What treatments have been developed for PMS and PMDD?

Over 40 years, hundreds of compounds have been patented for PMS and PMDD, including hormone therapies, antidepressants, vitamins, minerals, supplements, and newer drugs affecting brain chemistry.

 Early or limited evidence

Women with PMS and PMDD (5-8 percent with severe PMDD)

## What they did

Historical review of patent filings from 1963 onward for treatments of premenstrual syndrome and premenstrual dysphoric disorder.

## What they found

Approximately 5-8 percent of women report premenstrual symptoms severe enough to impair daily function and suffer from PMDD, with many more reporting milder PMS symptoms. Hundreds of patented treatments include hormone-based therapies, serotonergic drugs (antidepressants), vitamins and minerals, dietary supplements, compounds with GABAergic activity, and gonadotropin-releasing hormone antagonists.

## What it means for you

Many treatment options exist for PMS and PMDD, reflecting evolving understanding of these disorders. This is a review of patents, not clinical evidence of how well these treatments actually work.

5-8%

women with PMDD

## About the study

Original title Therapeutic patents for the treatment of premenstrual syndrome and premenstrual dysphoric disorder: historical perspectives and future directions Authors Lori E. Ross, Meir S Steiner Journal Expert Opinion on Therapeutic Patents Year 2003 Study design Review What was tested Various treatments for PMS and PMDD Read the paper [doi.org/10.1517/13543776.13.10.1491](https://doi.org/10.1517/13543776.13.10.1491)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2024

What are the best treatments for PMDD and PMS?

Guideline, 2023

How are GnRH agonists used to treat PMDD that doesn't respond to standard medications?

Review, 2022

What causes severe PMS and what treatments work?

Systematic review, 2022

What are the best treatments for PMDD and PMS?

Review, 2018

What are the most effective treatments for premenstrual syndrome and PMDD?

Review, 2015

What do we know about PMS and PMDD and how are they treated?

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