--- title: What research topics and methods have scientists focused on when studying PMS and PMDD? description: Scientists have focused research on PMS and PMDD primarily through double-blind medication trials, with recent trends shifting toward understanding steroid ho url: https://niyora.com/research/papers/top-100-cited-papers-on-premenstrual-syndrome-premenstrual-dysphoric-disorder-a-2022/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - What research topics and methods have scientists focused on when studying PMS and PMDD? Randomised trial, 2022 # What research topics and methods have scientists focused on when studying PMS and PMDD? Scientists have focused research on PMS and PMDD primarily through double-blind medication trials, with recent trends shifting toward understanding steroid hormone pathways and genetic factors. Moderate study design Analysis of 100 most-cited research papers on PMS and PMDD published between 1999-2017 ## What they did Researchers analyzed the 100 most-cited scientific papers on PMS and PMDD published between 1999 and 2017. They examined where and when these papers were published, which institutions led the research, and what topics the papers focused on using citation tracking software. ## What they found The 100 most-cited papers were published in 55 journals across 24 countries, with the US producing the most research. Top institutions were University of Pennsylvania, Yale, and the National Institute of Mental Health. Main research areas were obstetrics, gynecology, psychiatry, and reproductive biology. Most common topics were double-blind trials, fluoxetine and sertraline medications, efficacy, prevalence, depression, progesterone, and placebo. Recent trends focus on epidemiology, steroid hormone pathways, and genetics. ## What it means for you This analysis shows that scientists have historically focused on medications and controlled trials to understand PMS and PMDD. Newer research is exploring how hormones and genes affect symptoms. However, this analysis does not tell us whether any specific treatment actually works for PMS, as it only examines which research papers have been most influential. 100 most-cited papers analyzed 55 different journals represented 24 countries with published research ## About the study Original title Top 100 Cited Papers on Premenstrual Syndrome/Premenstrual Dysphoric Disorder: A Bibliometric Study Authors Gao M, Zhang H, Wang C et al. Journal Frontiers in psychiatry Year 2022 Study design Randomised trial What was tested None, this is a review of other published research Open access Yes Read the paper [doi.org/10.3389/fpsyt.2022.936009](https://doi.org/10.3389/fpsyt.2022.936009) Original abstract Background: Premenstrual syndrome/premenstrual dysphoric disorder is a serious condition affecting women worldwide, causing clinically significant distress or interference. Therefore, solving these diseases has become the utmost concern worldwide, culminating in numerous studies. In this study, we performed bibliometric analysis on the 100 most cited papers with the aim of identifying research hot spots and trends in this field. Methods: We screened the Science Citation Index Expanded (SCIE) of Web of Science (WOS) to identify the top 100 cited studies on PMS/PMDD. Next, we analyzed relevant literature from various journals, countries/regions, institutions, authors, and keywords. Finally, we used VOSviewer and Citespace software to generate knowledge maps and identify hot spots and trends. Results: The top 100 highly cited studies were published in 55 journals, between 1999 and 2017, across 24 countries/regions around the world. Most articles were published in Obstetrics and Gynecology, whereas Psych neuroendocrinology had the largest average number of citations per paper. The United States had the highest number of publications, followed by England, Canada, and Sweden. The top three institutions that published the highly cited literature were the University of Pennsylvania, Yale University, and National Institute of Mental Health (NIMH). Obstetrics, Gynecology, Psychiatry, and Reproductive Biology were the main research directions, whereas the top 10 Co-occurrence of Keywords included double-blind, fluoxetine, efficacy, prevalence, epidemiology, phase sertraline treatment, depression, progesterone, placebo, and placebo-controlled trial. Results from cluster analysis indicated that more comprehensive epidemiology and steroid pathogenesis have gradually become the hot spots and trends. Conclusion: These findings demonstrated that bibliometric analysis can intuitively and rapidly reveal the frontiers and hot spots of research in PMS/PMDD. Notably, epidemiology, steroid pathogenesis, GABAA receptor delta subunits, and double-blind placebo-controlled trials are potential areas of focus for future research. Reproduced under CC-BY. ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Neurosteroids (allopregnanolone)](https://niyora.com/research/topics/treatment-neurosteroids/)[Students and academic performance](https://niyora.com/research/topics/life-area-education/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Review, 2017 What causes PMDD and what are the best treatments? Guideline, 2016 What are the best standards for diagnosing and managing premenstrual disorders? Randomised trial, 2002 Are SSRIs the best treatment for PMDD? Study, 2026 What treatments work for PMDD? Review, 2025 What causes PMDD and why is it hard to function? Randomised trial, 2024 Does sertraline change brain chemicals in people with PMDD, and does this relate to symptom improvement? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗