---
title: Does alprazolam help premenstrual dysphoria? | Niyora
description: Yes. Alprazolam was significantly superior to placebo in treating late luteal phase dysphoric disorder based on physicians' ratings and patients' reports.
url: https://niyora.com/research/papers/treatment-of-premenstrual-dysphoria-with-alprazolam-a-controlled-study-1990/
---

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- Does alprazolam help premenstrual dysphoria?

Randomised trial, 1990

# Does alprazolam help premenstrual dysphoria?

Yes. Alprazolam was significantly superior to placebo in treating late luteal phase dysphoric disorder based on physicians' ratings and patients' reports.

 Moderate study design

30 women with late luteal phase dysphoric disorder

## What they did

Double-blind, randomized crossover trial. 30 women with late luteal phase dysphoric disorder received alprazolam or placebo in random order. Outcomes were measured by physicians' global ratings and patients' daily prospective ratings and retrospective assessments. The study used extensive screening, placebo washout, and had women serve as their own controls.

## What they found

Alprazolam was significantly superior to placebo based on physicians' global ratings and patients' prospective daily and retrospective assessments.

## What it means for you

Alprazolam may help premenstrual dysphoria. The study's improved design with extensive screening, placebo washout, and prospective ratings may explain why they found a significant drug-placebo difference.

30

Women who completed the study

## About the study

Original title Treatment of premenstrual dysphoria with alprazolam. A controlled study Authors Harrison WM, Endicott J, Nee J Journal Archives of general psychiatry Year 1990 Study design Randomised trial What was tested Alprazolam Read the paper [doi.org/10.1001/archpsyc.1990.01810150070011](https://doi.org/10.1001/archpsyc.1990.01810150070011)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Premenstrual exacerbation (PME)](https://niyora.com/research/topics/condition-pme/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Anxiolytics and other psychotropics](https://niyora.com/research/topics/treatment-anxiolytics/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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