---
title: Does the birth control pill containing drospirenone and ethinyl estradiol help treat PMDD?
description: The limited research available suggests it may help, and the pill has good tolerability and other health benefits, but more studies are needed to be sure.
url: https://niyora.com/research/papers/treatment-of-premenstrual-dysphoric-disorder-pmdd-with-a-novel-formulation-of-2007/
---

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- Does the birth control pill containing drospirenone and ethinyl estradiol help treat PMDD?

Randomised trial, 2007

# Does the birth control pill containing drospirenone and ethinyl estradiol help treat PMDD?

The limited research available suggests it may help, and the pill has good tolerability and other health benefits, but more studies are needed to be sure.

 Early or limited evidence

Women with PMDD (review of clinical trials)

## What they did

Reviewed recently published placebo-controlled randomized studies testing the birth control pill containing drospirenone and ethinyl estradiol for treating PMDD.

## What they found

Several placebo-controlled randomized studies tested this pill combination for PMDD treatment. The results of these trials were encouraging. The pill offers high contraceptive efficacy, good cycle control, good tolerability, and a favorable impact on lipid and glucose metabolism.

## What it means for you

The evidence so far suggests this pill may be helpful for PMDD and may offer benefits beyond symptom relief. However, this is a review of existing research rather than a new study, and the review emphasizes that further studies are needed before firm conclusions can be drawn.

## About the study

Original title Treatment of premenstrual dysphoric disorder (PMDD) with a novel formulation of drospirenone and ethinyl estradiol Authors De Berardis D, Serroni N, Salerno RM et al. Journal Therapeutics and clinical risk management Year 2007 Study design Randomised trial What was tested Drospirenone-ethinylestradiol as combined oral contraceptive for PMDD Open access Yes Read the paper [https://pubmed.ncbi.nlm.nih.gov/18472980/](https://pubmed.ncbi.nlm.nih.gov/18472980/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[SSRIs and antidepressants](https://niyora.com/research/topics/treatment-ssri/)[Oral contraceptives and drospirenone](https://niyora.com/research/topics/treatment-hormonal-contraceptives/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)[Diuretics and other drugs](https://niyora.com/research/topics/treatment-diuretics-other-drugs/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

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