---
title: Does lisuride maleate, a dopamine medication, reduce PMS symptoms?
description: Symptoms improved significantly, with headaches dropping from 85.7% to 20% and other symptoms also improving. However, this was a small study with no control
url: https://niyora.com/research/papers/treatment-of-premenstrual-tension-syndrome-pms-with-lisuride-maleate-1996/
---

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- Does lisuride maleate, a dopamine medication, reduce PMS symptoms?

Cohort study, 1996

# Does lisuride maleate, a dopamine medication, reduce PMS symptoms?

Symptoms improved significantly, with headaches dropping from 85.7% to 20% and other symptoms also improving. However, this was a small study with no control group, so we cannot be sure how much improvement came from the drug versus placebo.

 Early or limited evidence

35 women aged 19-35 with PMS diagnosis

## What they did

35 women aged 19-35 with PMS and no other gynecological disorders were treated with lisuride maleate 0.3 mg daily (split into 3 doses) for 3 months. Researchers measured symptom severity and hormone levels before and after treatment.

## What they found

All measured symptoms improved significantly: headaches from 85.7% to 20%, breast pain from 91.4% to 25%, bloating from 74.2% to 40%, lower leg swelling from 85.7% to 30%, and leg pain from 61% to 34%. Hormone levels showed small changes in FSH, progesterone, and prolactin.

## What it means for you

Lisuride maleate produced large symptom reductions. However, without a control group we cannot know if improvements came from the drug or from placebo or time alone. Adverse events were reported by 20 patients, and 1 withdrew early due to fatigue and headache. Hormone levels were only measured at one time point, so it is unclear how hormones actually changed.

85.7% to 20%

headache reduction

91.4% to 25%

breast pain reduction

74.2% to 40%

bloating reduction

## About the study

Original title [Treatment of premenstrual tension syndrome (PMS) with lisuride maleate] Authors López-Rosales C, Aguilar-Guerrero JA, García-Moreno L Journal Ginecologia y obstetricia de Mexico Year 1996 Study design Cohort study Participants 35 What was tested Lisuride maleate 0.3 mg daily for 3 months (dopamine receptor agonist) Read the paper [https://pubmed.ncbi.nlm.nih.gov/9019440/](https://pubmed.ncbi.nlm.nih.gov/9019440/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Anxiety and tension](https://niyora.com/research/topics/symptom-anxiety/)[Bloating, breast tenderness and physical symptoms](https://niyora.com/research/topics/symptom-physical-symptoms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)

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