---
title: Does danazol help severe PMS symptoms? | Niyora
description: Yes, most PMS symptoms improved more with danazol than placebo, though there were minor side effects. A double-blind controlled study provides good evidence.
url: https://niyora.com/research/papers/treatment-of-the-premenstrual-syndrome-a-double-blind-placebo-controlled-cross-1989/
---

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- Does danazol help severe PMS symptoms?

Randomised trial, 1989

# Does danazol help severe PMS symptoms?

Yes, most PMS symptoms improved more with danazol than placebo, though there were minor side effects. A double-blind controlled study provides good evidence.

 Strong study design

Women with severe premenstrual syndrome

## What they did

Double-blind placebo controlled crossover study. Women tracked symptoms daily using the Moos menstrual distress questionnaire over multiple cycles.

## What they found

Most common premenstrual symptoms improved more with danazol 400 mg/day than with placebo. Treatment was effective despite minor side effects.

## What it means for you

Danazol can help severe PMS symptoms, but the abstract does not specify sample size or total study duration.

400

mg/day danazol dose

## About the study

Original title Treatment of the premenstrual syndrome: A double blind placebo controlled cross over study using danazol Authors David H. Gilmore, Robert J. S. Hawthorn, D. M. Hart Journal Journal of Obstetrics and Gynaecology Year 1989 Study design Randomised trial What was tested Danazol 400 mg/day versus placebo Read the paper [doi.org/10.3109/01443618909151073](https://doi.org/10.3109/01443618909151073)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[GnRH agonists and ovarian suppression](https://niyora.com/research/topics/treatment-gnrh/)

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