---
title: Does ulipristal acetate help women with PMDD? | Niyora
description: Yes. Women taking ulipristal acetate experienced improvement in irritability and depression, and half of the women achieved complete remission of PMDD.
url: https://niyora.com/research/papers/ulipristal-acetate-shows-promise-for-treatment-of-pmdd-2021/
---

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- Does ulipristal acetate help women with PMDD?

Study, 2021

# Does ulipristal acetate help women with PMDD?

Yes. Women taking ulipristal acetate experienced improvement in irritability and depression, and half of the women achieved complete remission of PMDD.

 Strong study design

Women with PMDD in a placebo-controlled trial

## What they did

Women with PMDD received either ulipristal acetate or placebo in a controlled trial. Researchers measured whether irritability and depression symptoms improved.

## What they found

Women taking ulipristal acetate experienced improvement in irritability and depression symptoms. Half of the women taking the medication achieved full remission of PMDD symptoms.

## What it means for you

Ulipristal acetate appears to be an effective treatment for PMDD, helping women reduce irritability and depression with some women achieving complete remission. This is a placebo-controlled trial design, which is a strong way to test whether a treatment actually works.

50%

Women who achieved full remission

## About the study

Original title Ulipristal acetate shows promise for treatment of PMDD Journal The Brown University Psychopharmacology Update Year 2021 Study design Study What was tested Ulipristal acetate versus placebo Read the paper [doi.org/10.1002/pu.30702](https://doi.org/10.1002/pu.30702)

## Topics

[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Estradiol, progesterone and hormone therapy](https://niyora.com/research/topics/treatment-hormone-therapy/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Survey study, 2022

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Randomised trial, 2021

Does ulipristal acetate (a progesterone blocker) treat PMDD?

Systematic review, 2014

Do estrogen and progesterone change how the brain processes emotions and decisions?

Systematic review, 2008

What treatments work best for PMS and PMDD?

Randomised trial, 2003

What treatments work for PMS and PMDD?

Randomised trial, 2025

Does blocking progesterone change brain structure in people with PMDD?

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