---
title: Do estrogen patches help with menopausal symptoms? | Niyora
description: In this small study, 75% of women showed improvement in menopausal symptoms after 9 weeks of treatment with estrogen patches.
url: https://niyora.com/research/papers/use-of-estrogens-in-skin-patches-in-treatment-of-pre-menstrual-syndrome-1992/
---

- [Niyora](https://niyora.com/)
- [Research](https://niyora.com/research/)
- [Library](https://niyora.com/research/library/)
- Do estrogen patches help with menopausal symptoms?

Study, 1992

# Do estrogen patches help with menopausal symptoms?

In this small study, 75% of women showed improvement in menopausal symptoms after 9 weeks of treatment with estrogen patches.

 Early or limited evidence

33 women aged 30 to 65

## What they did

33 women aged 30 to 65 received estrogen patches (Estraderm TTS-50) containing 0.004 grams of estradiol. The patches were worn for 3 weeks each month, for 9 weeks total. Researchers measured symptoms before, during, and after treatment using a standard symptom scale and blood hormone tests.

## What they found

After 9 weeks, 75% of women showed improvement in symptoms. The symptom score decreased, and estradiol levels increased in their blood.

## What it means for you

Estrogen patches may help some women with menopausal symptoms. However, this was a small study with no control group to compare to, so we cannot be sure the improvement came from the patches or from other causes.

33

women in the study

75%

showed improvement

9 weeks

total duration of treatment

## About the study

Original title [Use of estrogens in skin patches in treatment of pre-menstrual syndrome] Authors Liber Z, Spiewankiewicz B, Stelmachów J Journal Polski tygodnik lekarski (Warsaw, Poland : 1960) Year 1992 Study design Study Participants 33 What was tested Estraderm TTS-50 patches containing 0.004 grams of 17-estradiol, worn for 3 weeks each month for 9 weeks total Read the paper [https://pubmed.ncbi.nlm.nih.gov/1305712/](https://pubmed.ncbi.nlm.nih.gov/1305712/)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Perimenopause and menopause](https://niyora.com/research/topics/comorbidity-perimenopause/)

Research tells you what helps on average. Niyora helps on the day it hits.

Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor.

## Related studies

Systematic review, 2026

Why do some women experience mood changes linked to their menstrual cycle?

Guideline, 2024

How should Xiangshao Granules be prescribed for premenstrual tension syndrome?

Systematic review, 2023

Does saffron help with PMS, labor pain, and menopause symptoms?

Cohort study, 2023

Do women with premenstrual disorders go through menopause earlier and have worse hot flashes?

Review, 2018

Which women are most likely to experience hot flashes during menopause?

Review, 2017

Can combining different types of treatments help PMS more than using one approach alone?

Ask AI about this page

Copy prompt

ChatGPT

↗

Claude

↗

Perplexity

↗

Google AI Mode

↗

Grok

↗