---
title: Does Vitex agnus-castus reduce migraines in women with PMS? | Niyora
description: In this open-label study of women with both PMS and migraines, over 40% experienced major reduction in migraine frequency and duration. Without a control grou
url: https://niyora.com/research/papers/use-of-vitex-agnus-castus-in-migrainous-women-with-premenstrual-syndrome-an-open-2013/
---

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- Does Vitex agnus-castus reduce migraines in women with PMS?

Randomised trial, 2013

# Does Vitex agnus-castus reduce migraines in women with PMS?

In this open-label study of women with both PMS and migraines, over 40% experienced major reduction in migraine frequency and duration. Without a control group, we cannot be certain the improvement was due to Vitex.

 Early or limited evidence

100 women with PMS and migraines who completed treatment

## What they did

107 women with both PMS and migraines took Vitex agnus-castus 40mg daily for 3 months. Effects on both PMS symptoms and migraine attacks were assessed. 100 women completed the study.

## What they found

For PMS: 66 women reported dramatic symptom reduction, 26 reported mild reduction, and 8 reported no effect. For migraines, 42% experienced a reduction of more than 50% in monthly migraine attack frequency, and 57% experienced a reduction of more than 50% in monthly days with headache. No patients reported notable side effects.

## What it means for you

Vitex agnus-castus was well-tolerated and associated with improvement in both PMS symptoms and migraine frequency in this group. However, this was an open-label study with no control group, so a placebo-controlled trial is needed to determine if benefits are truly due to the treatment.

100

women completed study

42%

had more than 50% reduction in migraine frequency

57%

had more than 50% reduction in migraine days

## About the study

Original title Use of Vitex agnus-castus in migrainous women with premenstrual syndrome: an open-label clinical observation Authors Ambrosini A, Di Lorenzo C, Coppola G et al. Journal Acta neurologica Belgica Year 2013 Study design Randomised trial Participants 107 What was tested Vitex agnus-castus 40mg daily for 3 months Read the paper [doi.org/10.1007/s13760-012-0111-4](https://doi.org/10.1007/s13760-012-0111-4)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Pain and headache](https://niyora.com/research/topics/symptom-pain/)[Vitex agnus-castus (chasteberry)](https://niyora.com/research/topics/treatment-vitex/)[Other herbal medicine](https://niyora.com/research/topics/treatment-herbal-other/)[Migraine](https://niyora.com/research/topics/comorbidity-migraine/)

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