---
title: Does a depression-related blood marker change during the menstrual cycle?
description: No, the study found no clear relationship between this blood marker and menstrual cycle phase, PMS symptoms, or hormone levels in healthy women.
url: https://niyora.com/research/papers/variation-in-platelet-3h-imipramine-binding-during-the-menstrual-cycle-in-1992/
---

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- Does a depression-related blood marker change during the menstrual cycle?

Case-control study, 1992

# Does a depression-related blood marker change during the menstrual cycle?

No, the study found no clear relationship between this blood marker and menstrual cycle phase, PMS symptoms, or hormone levels in healthy women.

 Early or limited evidence

Healthy young women (sample size not specified)

## What they did

Study of healthy young women measuring a blood marker related to depression during different phases of their menstrual cycle. Researchers looked for relationships between the marker level, menstrual cycle phase, PMS symptoms, and hormone levels (progesterone and estradiol).

## What they found

No significant relationship was found between the blood marker and the phase of the menstrual cycle, PMS symptoms, progesterone level, or estradiol level.

## What it means for you

This blood marker doesn't change with the menstrual cycle in healthy women. However, the study only included healthy women without PMS, so findings might differ in women who have PMS. The study was conducted in a limited population, so we should be cautious about generalizing these results.

## About the study

Original title Variation in platelet [3H]imipramine binding during the menstrual cycle in healthy young women Authors Peter M. Ellis, C. Joy McIntosh, Russell R. Cooke Journal Human Psychopharmacology Clinical and Experimental Year 1992 Study design Case-control study What was tested None - observational study Read the paper [doi.org/10.1002/hup.470070107](https://doi.org/10.1002/hup.470070107)

## Topics

[Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/)

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