--- title: Does vitamin D help with PMS mood symptoms in young women with very low vitamin D? description: Yes, vitamin D significantly improved anxiety, irritability, sadness, and relationship problems, while placebo did not. This was in young women with severely url: https://niyora.com/research/papers/vitamin-d-supplementation-for-premenstrual-syndrome-related-mood-disorders-in-2016/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Does vitamin D help with PMS mood symptoms in young women with very low vitamin D? Randomised trial, 2016 # Does vitamin D help with PMS mood symptoms in young women with very low vitamin D? Yes, vitamin D significantly improved anxiety, irritability, sadness, and relationship problems, while placebo did not. This was in young women with severely low vitamin D levels. Moderate study design 158 girls aged 15 to 21 with PMS-related mood symptoms and severe vitamin D deficiency. ## What they did A trial with 80 women given vitamin D and 78 given placebo, aged 15 to 21 with very low vitamin D levels (10 ng/mL or lower). Women in the vitamin D group received 200,000 IU initially, then 25,000 IU every two weeks for 4 months. Women recorded mood symptoms throughout. ## What they found Anxiety scores dropped from 51 to 20. Irritability fell from 130 to 70. Crying easily decreased from 41 to 30. Sadness fell from 51 to 31. Problems with relationships dropped from 150 to 70. Vitamin D levels reached the normal range (35 to 60 ng/mL) after the first month. No meaningful changes occurred in the placebo group. ## What it means for you Vitamin D therapy can help young women with severe vitamin D deficiency and PMS-related mood problems. This study focused on girls with very low vitamin D, so results may not apply to women with normal vitamin D levels. 51 to 20 anxiety score decrease 130 to 70 irritability score decrease 35-60 ng/mL normal vitamin D range achieved ## About the study Original title Vitamin D Supplementation for Premenstrual Syndrome-Related Mood Disorders in Adolescents with Severe Hypovitaminosis D Authors Tartagni M, Cicinelli MV, Tartagni MV et al. Journal Journal of pediatric and adolescent gynecology Year 2016 Study design Randomised trial Participants 80 What was tested Vitamin D at 200,000 IU initially, followed by 25,000 IU every 2 weeks for 4 months. Read the paper [doi.org/10.1016/j.jpag.2015.12.006](https://doi.org/10.1016/j.jpag.2015.12.006) ## Topics [Premenstrual syndrome (PMS)](https://niyora.com/research/topics/condition-pms/)[Premenstrual dysphoric disorder (PMDD)](https://niyora.com/research/topics/condition-pmdd/)[Low mood and depression](https://niyora.com/research/topics/symptom-depression-mood/)[Vitamin D](https://niyora.com/research/topics/treatment-vitamin-d/)[Relationships and partners](https://niyora.com/research/topics/life-area-relationships/)[Adolescents and young people](https://niyora.com/research/topics/life-area-adolescents/) Research tells you what helps on average. Niyora helps on the day it hits. Calm down, see it another way, and decide what to say, with a PMS and PMDD app built by a doctor. ## Related studies Survey study, 2019 What lifestyle and sleep habits are linked to PMS in teenage girls? Interview study, 2019 Which PMDD symptoms are most common in college students? Survey study, 2014 Are depression and anxiety linked to period pain in teenage girls? Survey study, 2012 Is there a link between premenstrual symptoms and period pain in teenage girls? Survey study, 2026 Do teen girls with ADHD have more suicidal thoughts when angry before their period? Survey study, 2026 Do girls who experienced childhood abuse or neglect have higher PMDD symptoms? Ask AI about this page Copy prompt ChatGPT ↗ Claude ↗ Perplexity ↗ Google AI Mode ↗ Grok ↗