--- title: Anxiety disorders and OCD: 186 studies, explained | Niyora description: 186 studies on anxiety disorders and ocd and PMS or PMDD, each summarised in plain English: what was tested, who took part, what they found and what it means. url: https://niyora.com/research/topics/comorbidity-anxiety-disorders/ --- - [Niyora](https://niyora.com/) - [Research](https://niyora.com/research/) - [Library](https://niyora.com/research/library/) - Anxiety disorders and OCD # Anxiety disorders and OCD: what the research says 186 studies on anxiety disorders and ocd in PMS and PMDD, each explained in plain English. 7 of them use the strongest designs: randomised trials and systematic reviews. Survey study 66 Review 22 Study 20 Cohort study 19 Randomised trial 17 Case-control study 15 Systematic review, 2026 Can digital tools help diagnose PMDD? Digital tools show promise for diagnosing PMDD by helping you track symptoms, but most need more testing and better integration with healthcare systems before they're widely used. Review, 2024 What is premenstrual exacerbation and how does it affect different psychiatric illnesses? Premenstrual exacerbation is when psychiatric symptoms worsen during the premenstrual phase. Hormonal changes during the menstrual cycle create a vulnerable period for many psychiatric conditions, but premenstrual exacerbation remains poorly defined. Systematic review, 2022 Do mental health disorders get worse during the menstrual cycle? Yes, several mental health disorders like depression, panic attacks, eating disorders and borderline personality disorder clearly worsen around menstruation. The evidence is less clear for anxiety or bipolar disorder. Non-randomised trial, 2008 Can the Sheehan Disability Scale measure whether treatments work? Yes. The scale was able to tell the difference between treatments that worked and treatments that didn't in clinical trials. Review, 2004 How should doctors diagnose and treat PMS and PMDD? Doctors can now diagnose these conditions using specific prospective symptom tracking and have several evidence-based treatments. Antidepressants that increase serotonin, especially when taken only during the luteal phase, work best for severe symptoms. Randomised trial, 1999 Do SSRIs reduce premenstrual dysphoria symptoms? Yes. SSRIs work significantly better than placebo and faster than when used for depression or anxiety. Intermittent dosing (taking medication only before the period) may work even better than daily dosing. Cohort study, 1993 How common are premenstrual and menstrual symptoms in women? Menstrual symptoms are very common in women in the community and increase with age. Women with anxiety are more likely to report menstrual problems. Survey study, 2026 Are there different types or patterns of PMDD among Chinese college students? Yes. There are two patterns: one with severe emotional and physical symptoms, and another with milder symptoms. Women with painful periods were more likely to have the severe pattern. Randomised trial, 2026 Does clinical Pilates reduce PMS symptoms and improve physical fitness? Yes. Eight weeks of clinical Pilates, done twice weekly, significantly reduced PMS symptoms and improved fitness, core strength, and reduced fear of movement in women with PMS. Study, 2026 Do anxiety and depression get worse before your period if you already have a mental health condition? Yes. If you have depression, bipolar disorder, or other mental health conditions, symptoms often worsen before your period due to hormone changes. This can affect how well treatments work. Survey study, 2026 What lifestyle and work factors are linked to PMDD symptoms in Chinese nurses? 42.4% of Chinese nurses have PMDD symptoms. Risk is higher in those who work night shifts, do not exercise, drink alcohol, are overweight in a certain range, or have depression, anxiety, or poor sleep. Study, 2026 What are premenstrual syndrome and premenstrual dysphoric disorder? Between 5% and 8% of women have moderate-to-severe symptoms that cause significant problems with work, relationships, and daily life. These are called PMS or PMDD. PMDD is the most severe form. Survey study, 2026 Does the Chinese version of the PMS screening questionnaire work well? Yes. The Chinese version is reliable and valid for identifying PMS and PMDD in Chinese college students. Study, 2025 Can blood markers that predict depression after childbirth also predict PMDD? A blood marker linked to depression after childbirth also showed promise in identifying women with PMDD, particularly during the luteal phase of the menstrual cycle. Survey study, 2025 Does PMS make teenage girls more anxious and reduce their quality of life? Yes, PMS significantly increases social anxiety and reduces quality of life in teenage girls. The effect was stronger in urban areas and in school-going girls. Survey study, 2025 Is a Chinese version of a PMDD screening tool reliable and valid for identifying PMDD? Yes. The Chinese version is reliable and accurately identifies PMDD in college students. It can distinguish women with PMDD from those without. Cohort study, 2023 Are premenstrual disorders linked to depression, anxiety, and self-harm in teenage girls? Yes. Girls with premenstrual disorders have 4 to 7 times higher rates of depression, anxiety, self-injury, and suicide risk compared to boys and girls without the disorder. This suggests premenstrual disorders may cause much of the difference in mental health problems between teenage boys and girls. Cohort study, 2022 Do adverse childhood experiences increase risk of PMS and PMDD? Women who experienced adverse childhood events had significantly higher risk of PMS and PMDD. Those with 4 or more such experiences had 2.46 times higher risk than those with none. The link was stronger for PMDD than for PMS. Survey study, 2022 Did the COVID-19 pandemic change women's periods and mental health? Yes. More than half of women reported changes in their menstrual cycle, including more heavy bleeding, painful periods, and missed periods. Rates of depression, anxiety, and poor sleep were more than double what is normal, and these were connected to menstrual changes. Systematic review, 2022 Do anxiety disorders, PTSD and OCD get worse at certain points in the menstrual cycle? For some women, yes. A review of 14 studies found that symptoms of several anxiety-related disorders tend to flare around the days before and after the period starts, but this pattern doesn't happen in every woman. Survey study, 2021 Are migraines around the period worse than migraines at other times? Yes. Migraines during the menstrual window last much longer, come back more often, and are more intense than migraines at other times of the cycle. Case-control study, 2021 Does sleep quality change across the menstrual cycle in women with anxiety disorders? Sleep quality remained mostly stable across menstrual cycle phases in both groups. The only link found was that larger increases in estradiol were associated with fewer nighttime awakenings. Cohort study, 2020 Are women with PMDD more likely to have generalized anxiety disorder? Yes, women with generalized anxiety disorder were 7.65 times more likely to have PMDD than those without it. The connection between the two conditions was explained by depression and partly by behavior inhibition and irritability. Lab study, 2020 Does anxiety sensitivity change during different parts of the menstrual cycle? No, not much. Anxiety sensitivity remained relatively stable across the menstrual cycle phases tested, even in women with PTSD. Randomised trial, 2020 Does an oxaloacetate and vitamin C combination reduce emotional symptoms of PMS? Yes. The supplement significantly improved depression, anxiety, stress, and aggression, with depression improving by 54.1% and suicidal ideation reduced by 47.9%. Case-control study, 2020 Does fatigue change across the menstrual cycle, especially in women with anxiety? Mental fatigue increases during the high-hormone phase in healthy women, rising to levels that women with anxiety disorder experience. Physical fatigue does not change, and hormone levels alone do not explain fatigue. Cohort study, 2019 Do SSRIs help women who have both PMS and panic disorder? Yes. After six months of SSRI treatment, most symptoms improved though they persisted in reduced form. About 40 percent of women recovered completely. Survey study, 2019 Does the luteal phase worsen anxiety and checking behaviors? Checking behaviors and anxiety-related brain responses stay about the same between cycle phases, but they are more strongly linked during the luteal phase. Survey study, 2019 How common is PMDD in teenage girls? Nearly 5% of teenage girls surveyed had PMDD. Girls with PMDD also had higher levels of stress, depression, and anxiety. Case-control study, 2019 Does the menstrual cycle affect how women's brains process emotions? Women's brain activity during emotion processing changes with menstrual cycle phase. In the late-luteal phase, women showed reduced reward processing, less enjoyment, and more sadness compared to the mid-follicular phase and compared to men. Randomised trial, 2017 Can couples therapy help with severe PMS or PMDD more than individual therapy alone? Yes. Both one-to-one and couple-based CBT reduced premenstrual symptoms and distress compared to a wait-list control, and couple-based CBT added extra benefits for coping skills and relationship quality. This comes from a moderate-sized randomised trial, so results are promising but not definitive. Survey study, 2015 Does estradiol level affect how women respond to stress? Yes, women with high estradiol levels showed smaller stress responses in the brain and reported less emotional distress when exposed to a stressful task, compared to women with low estradiol levels. Survey study, 2015 Does progesterone affect brain response to emotions differently in anxious women? Yes. Women who are naturally more anxious show a stronger brain response to emotional pictures, and this response is strongest during the luteal phase when progesterone is high. Cohort study, 2015 What factors predict anxiety and depression during pregnancy and after birth? Women are at high risk for anxiety and depression around pregnancy and birth, especially those with prior mental health problems or poor social support, though symptoms vary widely between women. Survey study, 2014 Do women whose depression started early experience more premenstrual symptoms? Yes. Women with depression that started at an earlier age were more likely to have premenstrual symptoms. Because data was collected by recall, we cannot be sure about timing or whether premenstrual symptoms came before or after the depression. Review, 2014 Are mental health problems linked to gynecological conditions like PMS and PMDD? Yes. Anxiety and depression are common with PMS and PMDD and are frequently undetected and untreated, affecting women's work, social and personal lives. Randomised trial, 2013 Does psychological education reduce PMS symptoms in teenagers? Yes. Psychological education significantly reduced overall PMS severity and reduced anxiety and physical symptoms. Effects on depression were minimal, and the intervention did not improve difficulty in relationships. Cohort study, 2013 Do women who are prone to anxiety experience more severe menstrual symptoms? Women with higher anxiety sensitivity reported greater menstrual symptoms regardless of which phase of their cycle they were in, compared to women with lower anxiety sensitivity. This suggests anxiety sensitivity may be an important factor in how severe menstrual symptoms feel. Survey study, 2012 What psychiatric conditions are linked to PMDD in Korean women? About 2.4% of Korean women experience PMDD. Women with PMDD were much more likely to have depression, anxiety, PTSD, alcohol problems, insomnia, and suicidal thoughts than women without PMDD. Survey study, 2012 How does PMDD affect quality of life? Women with PMDD have lower quality of life than women without it, with more problems in emotional health, family relationships, and social connections, plus more depression and anxiety. Cohort study, 2012 How quickly does fluoxetine start working for PMDD symptoms? Very quickly. Fluoxetine improved irritability, sadness, anxiety, and mood swings within hours, with clear daily improvement by the second day. Study, 2012 Does anxiety sensitivity affect panic symptoms differently at different menstrual cycle phases? Women with higher anxiety sensitivity had more panicked thoughts during the premenstrual phase compared to the follicular phase, and compared to women with lower anxiety sensitivity. Physical panic symptoms did not differ clearly. Study, 2010 Does pregnancy or menstruation affect OCD symptoms? Yes. About 1 in 3 women with OCD saw symptoms start during pregnancy or after birth. Women whose OCD began during this time are more likely to have worsening with their period. Study, 2010 Does how the body responds to stress change during the menstrual cycle? Partly. Stress response is slightly different in follicular and luteal phases, and the type of stress matters. Anxiety response to mental stress was higher in the follicular phase. Cohort study, 2010 How common is PMDD in women with bipolar disorder? About 27% of women with bipolar disorder have a lifetime history of PMDD. When PMDD occurs with bipolar disorder, it is linked to more severe bipolar subtypes and other mental health conditions like postpartum depression and obsessive-compulsive disorder. Randomised trial, 2009 How quickly does paroxetine reduce premenstrual irritability? Very quickly. Paroxetine reduced premenstrual irritability within 14 hours, with significant improvement by day 3. Case-control study, 2009 Does alcohol use increase the risk of developing PMS or PMDD? Alcohol use is not strongly linked to developing PMS or PMDD. Starting to drink before age 18 or long-term drinking may minimally increase risk, but the increases are small. Randomised trial, 2008 How common are PMS and PMDD in teenage girls? At least 20% of adolescents have moderate-to-severe premenstrual symptoms that interfere with daily life. However, large research studies focused on teenagers have not been done, so exact numbers and the best treatments are not well understood. Guideline, 2006 What is the best treatment for PMDD and severe PMS? SSRIs are first-line therapy for PMDD and severe PMS. They can be taken continuously throughout the month, only during the luteal phase, or with higher doses in the late luteal phase depending on each person. Case-control study, 2006 Are hormone-related chemicals different in women with mood disorders during the menstrual cycle? Women with bipolar disorder and major depression had higher levels of progesterone and a related chemical (3alpha,5alpha-THPROG) during the luteal phase compared to healthy women. This difference was present whether or not they were taking medication. Review, 2004 How well does alprazolam work for anxiety and panic attacks? Alprazolam is more effective than placebo and works as well as some other medications for anxiety. It works within the first week but can impair thinking and driving skills. Review, 2004 Is premenstrual dysphoria a variant of panic disorder? PMDD and panic disorder both trigger panic in lab tests, but scientists haven't identified the connection. This doesn't prove PMDD is a type of panic disorder. Randomised trial, 2004 Does paroxetine controlled-release help PMDD symptoms? Yes, paroxetine CR was more effective than placebo for PMDD symptoms and caused less nausea than regular paroxetine in the first week. This summary reviews multiple well-designed trials. Cohort study, 2004 What risk factors cause PMDD to develop? Traumatic events, anxiety disorders, and high daily stress significantly increase the risk of developing PMDD. Women who already had subthreshold PMDD at the start were at highest risk. Review, 2003 Does bipolar disorder affect women differently than men? Yes. Bipolar disorder often starts later in women, who experience more depressive episodes and rapid mood cycling. The postpartum period is high-risk for onset or recurrence. Case-control study, 2003 Are progesterone-related brain molecules different in women with panic disorder? Women with panic disorder had higher levels of progesterone-related brain molecules during different phases of their menstrual cycle compared to healthy women. This suggests the brain may be overproducing these molecules. Randomised trial, 2002 Is fluoxetine or cognitive-behavioral therapy more effective for PMDD? Both work equally well after 6 months. Fluoxetine works faster and reduces anxiety more. Cognitive-behavioral therapy builds better coping skills and changes how women think about their symptoms. Randomised trial, 2002 Does myo-inositol help reduce PMDD symptoms? No, myo-inositol (12 g daily) did not reduce PMDD symptoms more than placebo. Cohort study, 2002 How common is PMDD and does it stick around? PMDD affects 5.8% of young women and tends to persist. Most women with PMDD also have anxiety or other mental health conditions, use healthcare more, and have higher suicide rates. Review, 2002 What are the reproductive-related mood disorders and how are they connected? Mood and anxiety disorders are more common in women around menstruation, after childbirth, and during perimenopause. They all appear linked to changes in ovarian hormones. Review, 2001 What is the best treatment for depression and anxiety disorders, including PMDD? SSRIs (a type of antidepressant) are the first-line treatment for most depression and anxiety disorders, as well as for PMDD. Other newer antidepressants are options if SSRIs don't work or cause side effects. Study, 2001 Do women with PMDD panic as easily when breathing carbon dioxide as people with panic disorder? Yes. Women with PMDD showed panic attacks when breathing carbon dioxide at rates similar to people with panic disorder, and higher than people without these conditions. Review, 2000 What conditions beyond depression can antidepressants treat? Newer antidepressants including SSRIs have FDA approval for several conditions including anxiety, obsessive-compulsive disorder, and panic disorder. Controlled studies also show they help premenstrual dysphoric disorder. Interview study, 2000 Are depression and personality disorders linked to PMDD? Yes. Women with depression are about 9 times more likely to have PMDD, and avoidant personality disorder is also linked to PMDD (mainly in women over 30). However, the study cannot show whether depression causes PMDD, PMDD causes depression, or if both are caused by something else. Randomised trial, 2000 Does having used benzodiazepines before make withdrawal symptoms worse when stopping them? No. Analysis of data from three clinical trials found that prior benzodiazepine use did not increase symptoms when stopping the medication, either in people with PMS or anxiety disorder. Case-control study, 2000 Do women with panic disorder have different menstrual cycle patterns in anxiety and stress response? Yes. Women with panic disorder showed stronger physical stress responses during the premenstrual phase and higher anxiety-related symptoms overall compared to controls. Review, 1999 Is premenstrual dysphoric disorder a distinct clinical disorder? Yes, according to expert consensus. PMDD has distinct characteristics, clear symptoms linked to the menstrual cycle, and responds differently to treatment than other mood disorders. Survey study, 1996 Is the Daily Symptom Report a reliable way to diagnose PMS? Yes, the Daily Symptom Report is a reliable way to diagnose PMS, with very high internal consistency of 0.92. It measures mood, behavior, pain, and physical symptoms separately. Randomised trial, 1995 Is paroxetine better than other antidepressants for treating severe PMS? Yes. Paroxetine reduced symptoms much more than placebo. It also worked better than maprotiline for most symptoms. Randomised trial, 1993 Does clomipramine taken only during the luteal phase help premenstrual syndrome symptoms? Yes, clomipramine during the luteal phase significantly reduced irritability and depression compared to placebo. The effect was notably larger than placebo, though the study was small. Review, 1990 Is buspirone an effective treatment for anxiety? Yes, buspirone works as well as benzodiazepine anxiety medications and significantly better than placebo for generalized anxiety disorder and chronic anxiety. It also has antidepressant effects, and it is safer because it does not cause dependence, though it works more slowly. Cohort study, 1989 Does anxiety from panic disorder get worse before a woman's period? No. Women with panic disorder did not have more anxiety before their period, unlike women with PMS. This suggests panic disorder is not affected by the menstrual cycle. Survey study, 1988 Do depressive symptoms cluster into patterns including a premenstrual syndrome pattern? Yes. Statistical analysis identified five symptom patterns: one matching major depression and another in younger women as premenstrual syndrome. This explains the gap between reported depression symptoms and diagnoses. Study, 1986 Do women with PMS have more mental health conditions than other women? Yes. Women seeking treatment for PMS have higher rates of depression-like mood disorders, extreme fears (phobias), obsessive-compulsive patterns, and alcohol or drug abuse compared to women in the general population. Cohort study, 1986 What are the characteristic mood patterns that distinguish women with and without PMS? The study identified characteristic mood patterns in women with and without menstrually-related mood syndrome. The abstract confirms these patterns differ between groups but does not specify what they are. Case report, 2026 Can anxiety and PMDD trigger binge drinking, and can medication help? This single case shows that a woman whose binge drinking episodes were triggered by anxiety and linked to her PMDD improved with medication: her anxiety and drinking urges decreased, and she had no new drinking episodes at 12 weeks. Interview study, 2026 Does acceptance and commitment therapy help people with anxiety and PMDD? One woman showed meaningful improvement in anxiety and psychological flexibility after 37 therapy sessions, and no longer met criteria for PMDD, though some period-related symptoms remained. This is just one person's experience. Survey study, 2026 Are PMDD, anxiety, and internet use linked to cognitive problems in women? In this study of women aged 19-45 with anxiety, those who also had PMDD, severe anxiety lasting 5 or more years, or problematic internet use showed associations with cognitive problems including memory and concentration difficulties. Case report, 2026 Can antidepressants cause stomach problems that only happen during menstruation? One woman taking antidepressants developed nausea, vomiting, and diarrhea only during her menstrual period. The problem improved when her dose was lowered. Survey study, 2026 Do emotional regulation and resilience change during the menstrual cycle in women with PMDD? Women with PMDD have much higher depression and anxiety than other women, especially before their period. Their ability to handle emotions and bounce back from stress is significantly lower during that time. Review, 2026 Is premenstrual dysphoric disorder now recognized in the international diagnosis system? Yes. ICD-11 now officially recognizes premenstrual dysphoric disorder as a depressive disorder, with seven new specifiers to describe depressive disorders. Specific guidance for children and adolescents still needs more research. Review, 2026 Can the brain's perception of internal body signals explain premenstrual syndrome? This is a new theoretical idea that PMS may involve abnormal brain perception of internal signals like heartbeat and hormones. The theory has not yet been tested through research. Survey study, 2026 How common is PMS and PMDD in Pakistan and how do they relate to mental health? PMS was found in 36.2% and PMDD in 8.5%. Both were linked to higher stress and depression, and worse quality of life. Systematic review, 2026 Does the menstrual cycle affect obsessive-compulsive disorder symptoms? Yes, all 12 studies found that OCD symptoms worsened during the premenstrual phase. However, most research relied on self-reports rather than objective measurements. Survey study, 2026 Does smartphone use affect PMS symptoms through sleep? Smartphone use is linked to worse sleep and more PMS symptoms. Poor sleep partly explains the connection between smartphone use and PMS. Survey study, 2025 Is there a link between premenstrual syndrome and obsessive-compulsive symptoms? Yes, 74.2% of young women had PMS and showed significantly higher obsessive-compulsive symptoms than those without PMS, particularly in rumination. The link suggests PMS and psychological symptoms are connected. Survey study, 2025 What factors increase suicide risk in young women with PMDD? About 28% of young women with PMDD have current suicide risk, with risk higher in those with panic disorder, depression, childhood trauma, or non-white skin color. The evidence is limited because only 128 women were assessed in one location. Case-control study, 2025 Do certain hormone-related brain chemicals predict how bad premenstrual depression and anxiety will be? In this small study, women with a PMDD-like condition had higher levels of a calming hormone (allopregnanolone) early in the cycle, and higher levels of it predicted worse later depression and anxiety. The sample is small, so this is an early finding, not a proven cause. Survey study, 2025 Does a new Turkish questionnaire work well to screen for PMDD? Yes, in this study the questionnaire showed strong reliability and was very good at telling apart people with and without PMDD. Lab study, 2025 How does Shuyu capsule help depression during the premenstrual phase? This mouse study shows the medicine may work by increasing specific brain nerve cells and reducing a receptor protein. Results cannot yet be confirmed in women with PMDD. Study, 2025 Could taking a combination of vitamins and minerals help with PMS and PMDD symptoms? This paper proposes a theoretical framework linking low or borderline vitamin and mineral intake to many health problems, including PMS and PMDD, but it is not a new study testing a supplement in women, so it cannot tell us how well any particular combination actually works. Survey study, 2024 Are PMS or PMDD linked to different features of bipolar disorder in women? Yes. Women with bipolar disorder and PMS or PMDD became ill at younger ages, had worse depression symptoms with more anxiety and thinking problems, and were more likely to have OCD or family history of mental illness. This is observational, so we cannot prove cause and effect. Survey study, 2024 Does stress affect the menstrual cycle in college students? Yes, there is a significant relationship between stress level and menstrual cycle in this study. However, this is cross-sectional so we cannot be sure stress causes menstrual changes rather than the reverse. Interview study, 2022 Are doctors correctly diagnosing PMDD or mistaking it for depression or anxiety? All four women interviewed were initially misdiagnosed with depression or anxiety rather than PMDD. The key to accurate diagnosis was recognizing that symptoms followed the menstrual cycle. Survey study, 2022 Does depression or panic disorder increase the risk of severe PMS? Yes. Women with panic disorder had much higher rates of severe PMS (43%) than women with depression (16%) or no mental health conditions (10%). Cohort study, 2022 Do women with PMDD have differences in brain white matter structure? Yes. Women with PMDD showed differences in white matter structure in specific brain regions compared to healthy women. These differences were associated with symptom severity, but the clinical significance is unclear. Interview study, 2021 How does the female reproductive cycle affect anxiety in rodent studies? Female rodents show more anxiety responses during the late phase of their reproductive cycle, similar to the premenstrual phase in women. This is animal research, not human research, so findings may not directly apply to women. Survey study, 2021 Does fluoxetine reduce panic-like behavior during the premenstrual phase? In female rats, low-dose fluoxetine prevented an increase in panic-like behavior during late diestrus (the phase equivalent to the human premenstrual phase). A higher dose of fluoxetine did not have this effect. Survey study, 2021 Can obsessive-compulsive symptoms start or get worse during menstruation only? One woman with a history of panic disorder developed obsessive-compulsive symptoms that occurred only during her menstrual period. Since this is just one case, we cannot know how common this is. Review, 2021 How does the menstrual cycle affect anxiety and PTSD symptoms? The menstrual cycle and its hormones affect anxiety and PTSD symptoms. The clearest finding is premenstrual worsening of anxiety, and estradiol may help with trauma memory processing. Survey study, 2021 What are the research trends in PMS and PMDD studies from 1945 to 2018? Research on PMS and PMDD has grown over time. Recent research increasingly focuses on prevalence in young women and how anxiety and depression relate to menstrual cycle phases. Study, 2020 Does how women control disgust change during the menstrual cycle? In the follicular phase, suppressing disgust worked better than rethinking it. In the luteal phase, both strategies produced similar results. Lab study, 2020 Can Paeonia lactiflora extract reduce anxiety in rats with PMS-like symptoms? Yes. In rats with PMS-like anxiety, Paeonia lactiflora extract reduced anxious behavior and changed three brain chemicals involved in stress and mood. However, this is a rat study, so it does not directly show whether it would help people. Randomised trial, 2020 How should premenstrual syndrome be diagnosed and treated? PMS is diagnosed by tracking cyclical symptoms that appear 2-14 days before menstruation and disappear when menstruation starts. Both hormonal treatments like birth control pills and non-hormonal treatments like Vitex extract have been shown in research to be effective. Survey study, 2020 How common are PMS and PMDD in women with mood and anxiety disorders? PMS affected 47.5% and PMDD affected 13.0% of women with mood or anxiety disorders. Both were significantly linked to diet, menstrual patterns, and medication use. Cohort study, 2018 How common is PMDD in young adult women and what factors increase the risk? PMDD affected 17.6% of young adult women studied in Brazil and was more common in older women and those with lower income. The study relied on women remembering past symptoms, so the actual rate may differ. Case report, 2017 Can a combined oral contraceptive pill help PMDD in women who also have depression or anxiety? One 34-year-old woman with PMDD along with depression, anxiety, and other psychiatric conditions improved on a combined oral contraceptive pill. Her mood, anxiety, menstrual cramps, and ability to handle stress all got better. Survey study, 2017 What is the impact of having both bipolar disorder and premenstrual dysphoric disorder? Women with both conditions experience significantly worse bipolar illness: earlier onset, more rapid cycling, more mood episodes, and higher rates of anxiety disorders and other conditions. They also experience more severe symptoms during pregnancy and while taking oral contraceptives. Survey study, 2017 How common is PMS in adolescents with psychiatric problems and does it affect their quality of life? PMS was present in nearly 4 out of 5 adolescents in a psychiatric clinic and significantly lowered their quality of life. The more severe their PMS, the worse their quality of life became. Case-control study, 2017 Do women with PMS panic more during a breathing test, and does cycle timing matter? Yes. Women with PMS felt more intense panic symptoms during a CO2 breathing challenge, but only in the days just before their period, not earlier in the cycle. Survey study, 2016 Do women with PMDD also have postpartum depression? Rarely. Only about 11.7% of women with PMDD had a history of postpartum depression, suggesting these are separate conditions even though both involve mood changes. Survey study, 2015 Are menstrual problems linked to mental health issues? Yes. Girls with menstrual problems were clearly more likely to have stress and anxiety. Case-control study, 2015 Does feeling in control of anxiety affect how severe PMS symptoms feel? Possibly yes. Women who felt they had less control over anxiety reported worse PMS symptoms, regardless of which cycle phase they were in. This link was stronger than another anxiety measure studied. Study, 2015 Do women with more emotional sensitivity show different brain patterns during their menstrual cycle? Yes. Women who are more emotionally sensitive show different brain patterns than less sensitive women, especially during the second half of the cycle. Randomised trial, 2014 Does the menstrual cycle affect how well women can regulate their emotions? Yes. Women had more trouble controlling sadness and other emotions during their period. They had to work harder but were less successful. Case report, 2014 Does acetazolamide help PMDD symptoms in women who don't respond to standard treatments? In 8 women with PMDD who hadn't improved with standard treatments, adding acetazolamide 125 mg per day for 7-10 days before each period made their symptoms disappear. They stayed symptom-free for at least 12 months. Study, 2014 Does combining medication and therapy help PMDD? In one teenage girl with PMDD and anxiety, combining medication and therapy led to a good outcome. Combined treatment appeared to work better than either one alone. Survey study, 2013 Do women with OCD experience worse symptoms before their period? About half (49.7%) do experience premenstrual worsening of OCD symptoms. These women show higher rates of depression, anxiety, suicidal thinking, and specific obsessions about sex or religion. Survey study, 2013 Is there a link between PMS/PMDD symptoms and trauma from natural disasters? Yes, nine months after a major earthquake, girls with PTSD showed significantly higher rates and severity of PMS and PMDD symptoms. Symptom severity increased with PTSD severity. Survey study, 2013 Does stress sensitivity affect how the brain responds to emotional images across the menstrual cycle? The brain responds more strongly to emotional images during the late follicular phase than the luteal phase, and this effect is larger in women with high stress sensitivity. Survey study, 2013 Do stress-sensitive women respond to stress differently across the menstrual cycle? Women with high stress sensitivity show stronger stress responses during menstruation than women with low stress sensitivity, but not at other cycle phases. Case-control study, 2012 Do PMDD and generalized anxiety disorder affect memory and thinking in the same way during the cycle? No. In this study, women with generalized anxiety disorder had worse memory, attention and psychomotor function in the late luteal phase than women with PMDD, and both groups did worse than healthy women. Survey study, 2011 Why do women get panic disorder more often than men? This review proposes that women with anxiety sensitivity may be more vulnerable to panic disorder because progesterone and its brain chemical allopregnanolone interact differently during the premenstrual phase. The evidence is preliminary. Survey study, 2011 Do women with PMDD have higher cholesterol levels? Women with PMDD had higher average cholesterol (180.82 mg/dL) than women without PMDD (162.45 mg/dL). About 24% of women with PMDD had high cholesterol versus none of the controls. However, the sample was very small. Survey study, 2011 Do women with severe PMS have more personality disorders? Yes. 27% of women with severe PMS had a personality disorder compared to 0% of women without PMS. The most common was obsessive-compulsive personality disorder. Cohort study, 2010 How do anxiety disorders differ across different life stages? The provided summary focuses on anxiety in children and risk factors. The section about women and hormones is cut off in the provided text, so no conclusion about menstrual-related anxiety can be drawn. Survey study, 2010 Does premenstrual distress predict how women respond to challenges that trigger panic? Women with higher premenstrual distress had significantly greater panic symptoms when breathing CO2-enriched air, but this is preliminary evidence in a small study. Study, 2009 Can the standard mental health diagnostic interview assess PMS and PMDD adequately? No. The standard interview does not assess PMS, PMDD, or other women-specific mental health conditions. New diagnostic modules were developed to address this gap. Survey study, 2009 Are women who have mood problems from birth control pills more likely to have psychiatric disorders? Yes. Women who experienced mood-related side effects from combination birth control pills had higher rates of mood and anxiety disorders compared to women who had no mood problems from the pills. Survey study, 2008 Do genes related to mood and stress change during the menstrual cycle? One stress-related gene (FKBP5) showed lower activity in the follicular phase compared to other phases. Anxiety scores also changed during the cycle, but these two changes were not connected to each other. Case report, 2008 How do doctors diagnose and treat migraines linked to menstruation? Two case examples show that menstrual migraines are often diagnosed and managed together with other conditions like PMDD or depression. Treatment combines migraine prevention medication, management of mood disorders, and acute migraine treatments. Survey study, 2008 Do healthy women without PMDD have mood changes during their menstrual cycle? Yes, but the changes are small. Healthy women without PMDD showed small increases in anxiety, depression, and other negative mood symptoms from late follicular to late luteal phase. Survey study, 2008 How common is PMDD in African women and what factors are linked to it? 6.1% of Nigerian university students had PMDD. It was strongly linked to depression (17 times more likely), anxiety, panic disorder, painful periods, and a personality trait called neuroticism. Study, 2008 What causes severe PMS and how is it treated? Severe PMS is caused by the body's reaction to normal hormone changes during the menstrual cycle. It is treatable with hormonal methods or antidepressants. Survey study, 2006 Does the menstrual cycle affect how severe OCD symptoms are? Yes. For many women with OCD, symptoms get worse before their period, with nearly half reporting this pattern. The menstrual cycle should be considered when assessing OCD severity. Review, 2006 When mood changes seem tied to your cycle, is it actually PMDD? No. Many mood and anxiety symptoms tied to the menstrual cycle are not genuine PMDD. When true PMDD occurs, its impact on quality of life is similar to major depressive disorder. Review, 2006 How do birth control pills affect brain chemicals that control mood? Birth control pills reduce neuroactive steroid levels in the brain. Since these chemicals help regulate mood, lower levels might explain why some women experience negative mood symptoms on the pill. Review, 2005 How does acute tryptophan depletion help us understand mood disorders? Acute tryptophan depletion is a research method that temporarily lowers serotonin levels in the brain to study its role in depression, anxiety, sleep problems, and psychiatric conditions. Survey study, 2005 Does the menstrual cycle affect obsessive-compulsive disorder symptoms? Yes, for some women. OCD started at menarche in 22% of women and worsened premenstrually in 20%. It worsened after childbirth in 50% of women who became pregnant. Lab study, 2005 How do changes in brain chemistry during the menstrual cycle affect anxiety and seizures? During the high-progesterone phase of the cycle, specific brain chemicals increase the brain's ability to calm down, which reduces seizure risk and anxiety. Some women with PMDD or epilepsy may not have normal cycling of these chemicals, which could explain their symptoms. Survey study, 2005 How common are PMS and PMDD in female students, and what mental health problems go with them? PMS affected 15.3% and PMDD affected 4% of female hostel students. Psychiatric illness was present in 58.62% of these women. Lab study, 2005 When progesterone drops during the menstrual cycle, do brain changes occur that could explain anxiety in PMDD? Yes, according to this rat study. When progesterone was withdrawn, a specific type of brain receptor involved in anxiety control increased dramatically in numbers in key brain regions. Non-randomised trial, 2004 Does premenstrual dysphoric disorder affect how the heart's nervous system regulates itself? Women with PMDD showed reduced activity in the vagus nerve, which helps regulate the heart. The difference from women without PMDD was most clear during the non-symptom phase of the cycle. Survey study, 2004 What other mental health conditions often happen alongside PMDD? PMDD commonly occurs together with mood and anxiety disorders. This review does not report specific rates of how often this happens. Survey study, 2004 How common is PMS and premenstrual worsening of psychiatric symptoms in women with mental health disorders? Very common. Between 52% and 80% of women with anxiety, depression, or panic disorder reported PMS symptoms, and between 36% and 52% experienced worsening of their psychiatric symptoms before their period. Cohort study, 2004 Do anxiety levels and coping styles affect premenstrual distress? Yes. Women with high anxiety sensitivity used less helpful coping strategies and reported more premenstrual distress, especially when using avoidance coping. Survey study, 2003 Is cycle-related aggression linked to changes in breathing during the menstrual cycle? In rats prone to cycle-related aggression, breathing rate was higher during one phase of the cycle, whereas non-aggressive rats showed no breathing changes. This may help explain similar patterns in humans with PMDD. Survey study, 2003 Do hormone levels change during the menstrual cycle in women with depression? Yes. Women with depression had higher levels of a chemical called homocysteine in the early cycle compared to the late cycle, and overall higher levels than healthy women. Survey study, 2003 Is PMDD a form of depression, a form of anxiety, or something completely different? PMDD is a distinct condition, separate from both depression and anxiety. It is characterized more by irritability and mood swings than by depressed mood or anxiety. Non-randomised trial, 2003 How many women with PMS want to participate in research studies? Very few. Only 10% of women with current PMS symptoms agreed to participate, and only 22% of those who started confirmed their diagnosis by keeping daily symptom charts. Survey study, 2003 Is how much control women feel over their life linked to premenstrual symptoms? Yes. Women who felt they had less control over their circumstances were more likely to have premenstrual symptoms, anxiety, and depression. Women felt especially out of control during the premenstrual phase compared to other times in their cycle. Survey study, 2002 Does menstrual cycle phase affect asthma or anxiety symptoms? No. This study found no significant connection between menstrual cycle phase and these symptoms. The sample size was not reported in the abstract. Randomised trial, 2001 Do women with PMDD have a different panic response than other women? No. Two stress hormones (vasopressin and oxytocin) increased similarly during a panic test in women with PMDD and in women without PMDD, regardless of where they were in their menstrual cycle. Review, 2001 Can citalopram, an antidepressant, help premenstrual dysphoria? Yes, citalopram is an antidepressant shown in controlled trials to help premenstrual dysphoria, depression, anxiety, and other conditions. This review focuses on the drug's general benefits, not specifically on PMS. Study, 2001 Is taking sertraline every day or just before your period better for PMDD? Taking sertraline every day is better tolerated than taking it only before your period. However, many women in both groups stopped the medication due to side effects. Case-control study, 2001 Does breathing carbon dioxide trigger panic attacks in people with PMDD like it does in panic disorder? Yes, people with PMDD had panic attacks during CO2 breathing at similar rates to people with panic disorder. However, this was a very small study with only 10 PMDD participants, so results need confirmation in larger studies. Survey study, 2001 How common is premenstrual dysphoric disorder and how is it related to other psychiatric conditions? About 75-85% of women report some premenstrual symptoms, but only 10-15% seek care and 2-5% experience serious disruption to work or social life. PMS may worsen other psychiatric conditions. Non-randomised trial, 2001 Do people with PMDD have different breathing patterns? Yes. PMDD patients showed greater variation in their breathing patterns than women without PMDD. Survey study, 2000 Why do women get more anxious when hormone levels drop? Falling estrogen and progesterone levels may trigger anxiety and mood disorders by affecting how brain receptors that control anxiety and mood work. The exact mechanism is not yet fully understood. Review, 2000 Can SSRI antidepressants treat premenstrual syndrome? Yes, SSRIs are particularly effective for treating premenstrual syndrome symptoms. Survey study, 2000 Does premenstrual worsening of panic disorder increase suicide risk in women? Yes. Women with panic disorder who experienced premenstrual worsening had higher suicide risk scores and were more likely to be considered suicidal than women whose panic did not worsen premenstrually. This was independent of depression. Survey study, 2000 Are women with PMDD more likely to have had mental health problems? This review questions the common belief that women with PMDD have higher rates of past psychiatric disorders. It suggests this assumption may be premature, but does not provide new research to confirm either way. Non-randomised trial, 1999 Do women seeking PMS treatment actually have underlying mood or anxiety disorders? About 39% of women seeking PMS treatment meet criteria for mood or anxiety disorders. Mood disorders were about twice as common as anxiety disorders. Review, 1999 Do SSRI antidepressants work for PMDD? Yes, SSRIs are the treatment of choice for PMDD because they are effective, have acceptable side effects, and are well tolerated. Review, 1998 What does research say about diagnosing and treating PMS and PMDD? This review explains that careful symptom tracking and ruling out other conditions are key to diagnosing PMS, and that some promising drug treatments exist for PMDD, though it is unclear if they work as well for milder premenstrual symptoms. Survey study, 1997 How are anxiety symptoms and anxiety disorders linked to PMDD? PMDD appears linked to anxiety disorders. Women with PMDD often have anxiety histories, and treatments that work for anxiety also help PMDD, though this is a review of existing research rather than new original findings. Survey study, 1997 Does pregnancy or the menstrual cycle affect OCD symptoms? Some women's OCD worsened before their period (42 percent) and after childbirth (29 percent), suggesting hormones may play a role. However, most women's OCD did not change during pregnancy itself (69 percent had no change). Case-control study, 1997 Are PMDD and eating disorders related? Possibly. PMDD and eating disorders share high rates of mood and anxiety disorders and a personality trait called harm avoidance, but this small study cannot confirm they share a common cause. Survey study, 1997 Does the menstrual cycle affect compulsive hair-pulling? Yes. Women reported premenstrual worsening of hair-pulling urges, frequency, and difficulty controlling the behavior, with improvement during menstruation. Pregnancy effects were variable. Survey study, 1996 Do psychiatric symptoms get worse during certain phases of the menstrual cycle? Some reports suggest that psychiatric symptoms worsen during premenstrual and menstrual phases, but evidence is limited because most studies have been small and tracked women informally. Randomised trial, 1995 Does menstrual cycle phase affect anxiety response to CO2 in women with panic disorder? Yes. Women with panic disorder showed significantly stronger anxiety during the early follicular phase than the luteal phase after breathing a CO2 mixture. Controls showed no anxiety response. Case-control study, 1994 Is the stress hormone system different in women with severe PMS? Yes. Women with severe PMS have altered control of their stress hormone system, with cortisol responding differently to hormonal stimuli, suggesting reduced opioid receptor sensitivity. Study, 1994 Do women with both PMS and anxiety who have family alcoholism drink more before their period? Yes. 74% of women with family history of alcoholism on their father's side reported drinking more before their period, compared to only 22% without this family history. Non-randomised trial, 1993 Do women with PMDD react more strongly to lactate challenge? Yes. 58% of women with PMDD had panic responses to sodium lactate injection, compared to 0% of control women. Case-control study, 1993 Do women with both anxiety disorder and PMS have worse anxiety, and does the menstrual cycle affect it? Women with both anxiety disorder and PMS had worse symptoms in both menstrual phases, with clear worsening premenstrually. Even when assessed once, their ratings were influenced by how bad they felt premenstrually. Study, 1992 Can a chemical called lactate trigger panic attacks in women with PMS? Yes. In this study, infusing lactate triggered panic attacks much more often in women with PMS than in women without PMS, suggesting people with PMS may be more sensitive to this trigger, though this extra sensitivity was not mainly explained by also having panic disorder. Survey study, 1991 What mental health and social problems do women with PMS have? Most women seeking PMS treatment (67 percent) had a psychiatric disorder, with depression and anxiety being most common. Sexual dysfunction and social problems were also frequent. Cohort study, 1990 Does anxiety get worse before the period in women with panic disorder? Women with panic disorder reported afterward that their anxiety was worse before their period, but their daily diary records did not consistently show this pattern. The answer depends on how you ask the question. Case report, 1990 Can fear of menstruation that stops periods be treated with therapy? This single case shows that a woman whose periods had stopped due to fear of menstruation was helped by cognitive therapy (talking about her thoughts and beliefs), which increased her confidence and brought her periods back. Survey study, 1990 Do women with PMDD have a history of depression or other mental health problems? Yes. 78% of women with PMDD had a lifetime history of other mental disorders, most commonly depression. 29% of those who had given birth reported postpartum depression. Cohort study, 1988 Do anxiety and depression relate to menstrual symptoms in healthy women? Yes, there was an association between anxiety and depression scores and menstrual symptoms. Nearly half of the women reported menstrual symptoms. However, this does not prove whether mood causes symptoms, symptoms cause mood, or both stem from another cause. Study, 1988 Do panic attacks get worse before menstruation? The answer is unclear. When women looked back on their whole month, they said symptoms were worst in the week before menstruation. But when they rated symptoms every day or week, the changes were much smaller than expected. Review, 1988 Does caffeine make PMS worse? Yes. Caffeine may aggravate premenstrual syndrome symptoms, especially in people who are caffeine-sensitive or who consume heavy amounts chronically. Study, 1986 Do women with agoraphobia experience worse anxiety before their period? Yes, just over half of the women with agoraphobia in this study experienced worse anxiety before their period. Lab study, 1983 Does being in heat change how female rats remember what they learned? No. Female rats in heat did not show state-dependent memory, unlike male rats given a drug or stressed rats. Study, 1959 Does oxanamide help with premenstrual tension? Among 45 patients treated, 37 benefited from the medication, and 4 had mild side effects. 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