---
title: Effect of Perimenstrual Ovarian Steroid Supplement | PMS & PMDD trial
description: Completed. Clinical trial on Suicidal Ideation run by University of North Carolina, Chapel Hill in United States.
url: https://niyora.com/research/trials/effect-of-perimenstrual-ovarian-steroid-supplementation-on-nct03720847/
---

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- Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality

Completed

# Effect of Perimenstrual Ovarian Steroid Supplementation on Perimenstrual Suicidality

Ovarian Hormone Withdrawal and Suicide Risk: An Experimental Approach

Status Completed Registry ID NCT03720847 Type Interventional (tests a treatment) Phase Phase 4 Conditions Suicidal Ideation What is tested Estradiol Transdermal Patch 0.1 mg/24 hrs (drug); Oral Micronized Progesterone (drug); Inactive Clear Patch (drug); Placebo capsule (drug) Sponsor University of North Carolina, Chapel Hill Where United States Participants 30 Start 2016-12-31 Completion 2017-11 Last update 2019-02-04 Results posted Yes

## About the study

This within-person, crossover, 2-condition, placebo-controlled study compares the impact of two perimenstrual conditions on severity of suicidal symptoms in females with past-month suicidality but minimal risk of imminent suicide attempt. The two conditions are (1) natural perimenstrual withdrawal from estradiol and progesterone (during placebo), (2) perimenstrual stabilization of estradiol and progesterone using transdermal estradiol and oral micronized progesterone.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT03720847)

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