---
title: Stress & Premenstrual Symptoms Study | PMS & PMDD trial
description: Completed. Clinical trial on PMDD and Stress run by Johns Hopkins University in United States.
url: https://niyora.com/research/trials/stress-premenstrual-symptoms-study-nct02777372/
---

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- Stress & Premenstrual Symptoms Study

Completed

# Stress & Premenstrual Symptoms Study

Psychophysiology, Neurosteroids, and Stress in Premenstrual Dysphoric Disorder

Status Completed Registry ID NCT02777372 Type Interventional (tests a treatment) Phase Phase 4 Conditions PMDD, Stress, Mood What is tested Sertraline (drug) Sponsor Johns Hopkins University Where United States Participants 84 Start 2016-04-01 Completion 2021-12-01 Last update 2025-06-12 Results posted Yes

## About the study

This study that aims to evaluate the psychophysiology of premenstrual mood disorders (PMDs) at baseline and after treatment with sertraline. Participants will include women with PMDs and healthy female controls. Participation involves a baseline visit to determine eligibility and three study visits that include questionnaires and stress reactivity assessment via an acoustic startle paradigm. Female participants with PMDs will receive sertraline during the premenstrual phase.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT02777372)

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