---
title: The Influence of the Menstrual Cycle on Lithium an | PMS & PMDD trial
description: Completed. Study on Bipolar Affective Disorders and Cyclothymic Disorder run by Weill Medical College of Cornell University in United States.
url: https://niyora.com/research/trials/the-influence-of-the-menstrual-cycle-on-lithium-and-nct01385709/
---

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- The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels

Completed

# The Influence of the Menstrual Cycle on Lithium and Sertraline Blood Levels

Status Completed Registry ID NCT01385709 Type Observational (no treatment given) Conditions Bipolar Affective Disorders, Cyclothymic Disorder, Schizoaffective Disorder, Major Depressive Disorder Sponsor Weill Medical College of Cornell University Where United States Participants 29 Start 2008-08 Completion 2013-08 Last update 2017-02-20

## About the study

The aim of this study is to determine whether blood levels of lithium or sertraline are affected by different phases of the menstrual cycle and whether there is an effect on psychiatric symptoms. Subjects are seen for two visits: one visit during the luteal phase and one visit during the follicular phase of the menstrual cycle. On each visit, they will fill out a depression, anxiety and mania rating scale. Also at each visit a 20mL blood sample will be drawn to measure progesterone level and either a lithium or sertraline level, depending on which medication the patient takes. The primary hypothesis in this study is that blood levels of lithium and sertraline will be significantly lower in women during the luteal phase of the menstrual cycle than during the follicular phase. Examination will also be made of whether symptoms will increase in severity during the luteal phase as compared to the follicular phase. The investigators expect a negative linear association between symptom severity and blood level, i.e. expect symptom severity to worsen as blood levels of lithium or sertraline decrease.

Summary from ClinicalTrials.gov.

[See the full record](https://clinicaltrials.gov/study/NCT01385709)

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