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Survey study, 2017

Does ulipristal acetate, a fibroid medication, help PMS symptoms?

Possibly yes. 80% of women taking this medication reported improvement in PMS symptoms, though this study had no control group.

Early or limited evidence 80 women with uterine fibroids

What they did

80 women with uterine fibroids took ulipristal acetate and reported on their bleeding, period pain, side effects, and PMS changes on a questionnaire.

What they found

67 women (84%) showed improvement in bleeding. 54 women (67%) stopped menstruating. 58 women (70%) reported reduced pain. 80% reported improvement in PMS symptoms. Most women had no or infrequent side effects.

What it means for you

This progesterone-based medication helps fibroids and may also help PMS, but this is observational data without a comparison group. More controlled research is needed to be sure.

80

women studied

80%

improved PMS symptoms

84%

improved bleeding

About the study

Original title
An observation study of the clinical evaluation of symptom relief and side effects associated with taking ulipristal acetate (esmya) including its effect on pre-menstrual syndrome
Authors
Chen BF, Powell MC, O'Beirne C
Journal
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology
Year
2017
Study design
Survey study
Participants
80
What was tested
Ulipristal acetate, a progesterone receptor modulator

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